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Fibrogenesis
Fibrogenesis: Cellular and Molecular Basis is the first volume to provide a synopsis of the rapid progress that has been documented in fibrogenesis over last couple of years, which significantly enhanced our understanding of the pathomechanisms of fibrotic diseases. Knowledge on molecular and celluar basis of fibrotic diseases has provided opportunities to develop selective and effective gene-based therapeutic options. The chapters in this book have been selected to provide comprehensive information on fibrogenesis, which is not limited to any specific organ. Individual chapters present mechanisms of fibrotic diseases involving lung, liver, kidney, heart, blood vessels, and more. The relevance and significance of inflammatory cytokines, chemokines, transcriptional factors, fibrogenic molecules, signaling cascade, and matrix remodeling in fibrogenesis are explained in depth, providing the reader with current and updated information.
Progression of Chronic Renal Diseases
During the last few years, interest in research on the progression of chronic renal diseases has grown to the extent that this field is now in the mainstream of investigative nephrology. This interdisciplinary volume brings together the latest data from institutes at the forefront of current research. The contents cover a diverse range of topics including apoptosis in renal modeling and remodeling, the role of cytokines, growth factors and macrophages, the metabolism of interstitial collagen and collagenous materials, diabetic nephropathy, and vasoactive substances in renal injury. The use of methodology from morphometry to DNA recombinant technology illustrates the wide range of experimental approaches being adopted. Stimulating and up-to-date, this book is essential reading for nephrologists, biochemists, molecular biologists and all investigators interested in the mechanisms of renal disease progression.
New Perspectives in Regeneration
Regeneration, the homeostatic ability to maintain tissue structure in the face of normal cell turnover or loss of tissue damaged by trauma or disease, is an essential developmental process that continues throughout life. As recently as a decade ago, any serious discussion of the possibility of regeneration becoming a practical medical tool in the near future had the air of science fiction or over-optimistic speculation. The term “regenerative medicine” was certainly on many lips but few actually expected to soon see it applied in a clinical setting. A tidal wave of discovery has changed that and investigating the cellular mechanisms of natural regeneration has become one of the hottest t...
Recent Progress in Failing Heart Syndrome
Heart failure is a syndrome caused by a heart dysfunction that leads to insuf ficient blood in the peripheral tissues for their metabolic demands. This syn drome still remains an obscure clinical entity and even its definition is disputed. It has become increasingly apparent that heart failure may relate not only to cardiac dysfunction but also to other physiological alterations involved in the maintenance of circulatory homeostasis. In 1988, the Japanese Circulation Society organized a three-year project for research on heart failure. The research group consisted of ten investigators, all relatively young but well recognized internationally for their research accomplishments. This book repr...
The Sport Mega-Events of the 2020s
This book explores various social, cultural, political and economic issues through the lenses of various sport mega-events in the twenty-first century, including the Olympic Games, and the World Cup and European Championships in football. In a time where sport mega-events are closely followed by controversies, legacy discourses and questions of their governance, the chapters within this book showcase why sport mega-events continue to ignite important questions for scholars, commentators, fans and sport and political authorities. By covering various topics emerging around sport mega-events such as physical activity, legacies, rhetoric, media coverage, environmental impacts, diplomacy and spec...
Renal Fibrosis
This publication provides a synopsis of the rapid progress made in the field of renal cell biology during the last decade, progress which has resulted in a better conceptual understanding of the cellular and molecular mechanisms of fibrotic renal disease. These developments have provided new therapeutic choices and led to the discovery of gene-based therapeutic options. The topics covered in this book have been carefully selected from the immense number of aspects of the disease to provide essential information on the molecular basis of renal fibrosis. Individual chapters discuss topics such as proteinuria and tubulointerstitial injury, the roles and regulation of TGF-beta, chemokines, oxidant stress, matrix remodeling, significance of renal expression of NF-kappa, and the potential impact of cell death in renal fibrosis. Written so as to present the complex information as simply as possible, this publication will be a very useful tool for general health professionals involved in the fields of immunology and cell biology, as well as for clinicians and researchers within the fields of nephrology, pathology and matrix biology.
IgA Nephropathy Today
Primary IgA nephropathy has first been described as a new disease entity almost 40 years ago. This disorder, considered to be an immune-complex-mediated glomerulonephritis, is characterized by granular deposition of IgA (mainly IgA1) and C3 in the glomerular mesangial areas and is defined as nephropathy showing proliferative changes in the glomerular mesangial cells and increases in the mesangial matrices. Apart from being one of the most common types of chronic glomerulonephritis, it is also the most frequent case of end-stage renal disease. But even though continuing efforts have gradually clarified various aspects of the pathogenesis of the disease, specific treatment is not yet available...
Dermatology in Public Health Environments
Dermatological diseases are extremely common around the globe, and a systematic understanding of these conditions and their relationships with various epidemiological factors could provide insights to help governments and private institutions address the challenges they need to overcome in order to improve global health. This extensively revised second edition comprehensively discusses the fundamental areas of dermatological practice in public health. It features more than 900 figures, eight new chapters and two new sections: a) Dermatological Biopsy and Major Histopathological Patterns, exploring surgical methods for collecting cutaneous specimens from outpatients and the analysis of major ...
