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Heterogeneity of T Cells in Atherosclerosis Defined by Single-cell RNA-sequencing and Cytometry by Time of Flight
Abstract: The infiltration and accumulation of pro- and anti-inflammatory leukocytes within the intimal layer of the arterial wall is a hallmark of developing and progressing atherosclerosis. While traditionally perceived as macrophage- and foam cell-dominated disease, it is now established that atherosclerosis is a partial autoimmune disease that involves the recognition of peptides from ApoB (apolipoprotein B), the core protein of LDL (low-density lipoprotein) cholesterol particles, by CD4+ T-helper cells and autoantibodies against LDL and ApoB. Autoimmunity in the atherosclerotic plaque has long been understood as a pathogenic T-helper type-1 driven response with proinflammatory cytokine ...
Single-Cell OMICs Analyses in Cardiovascular Diseases
Single-cell OMICs analyses have recently become one of the most promising tools to probe biology at the cellular level, in large part due to its ability to address issues beyond the bulk analysis – a window into cellular heterogeneity. The ability to profile transcriptomic, epigenomic, proteomics, and metabolomics at the single cell level including more recently the spatial information has enhanced our ability to understand interactions between biomolecules in different contexts leading to the discovery of specific cellular subpopulations as well as biological mechanisms underlying pathologies which may be amenable to therapeutic interventions. The scale and availability of a variety of technologies to measure intricate molecular details have provided an impetus to research in many disease areas, including cardiovascular medicine.
AHA Scientific Sessions 2019 - Final Program
The American Heart Association’s Scientific Sessions 2019 is bringing big science, big technology, and big networking opportunities to Philadelphia, Pennsylvania this November. This event features five days of the best in science and cardiovascular clinical practice covering all aspects of basic, clinical, population and translational content.
Blood Brothers and Peace Pipes
The first academic book-length study devoted to Karl May festivals, a specific type of Wild-West-themed festivals that take place in Germany every summer, Blood Brothers and Peace Pipes introduces readers to a performance world that is popular at home yet virtually unknown elsewhere. Named for Karl May (1842-1912), arguably the most famous German writer of adventure fiction in the nineteenth and twentieth centuries, these thirteen or so festivals dramatize the exploits of May's most famous Wild West heroes, the Mescalero Apache Winnetou and his blood-brother, the German frontiersman Old Shatterhand, in entertaining theatre plays that use horses, other animals, stunts, and special effects on ...
Jan und die Kindsräuber
Dunkel und düster lag der Buchenwald von Gjorslev am Meer. Die Vögel, die tagsüberihren Gesang aus den dichten Kronen hatten erschallen lassen, waren längst verstummt, und lediglich das schwache Rauschen des Meeres durchdrang das Schweigen gleich Orgelmusik. ... Plötzlich wurde die Stille von Menschenstimmen gebrochen. Ein Auto hatte am Waldrand gehalten, und zwei dunkle Gestalten schritten langsam zum Ufer hinab.JAN ALS DETEKTIV - die spannende Kultbuchreihe ist zurück - toller denn je!REZENSION"Die Detektivgeschichten "Jan als Detektiv" für Buben und Mädchen von Knud Meister und Carlo Andersen sind spannend und logisch aufgebaut. Sie verbinden Abenteuer und Humor auf eine für Juge...
ECAI 2004
This is the Golden Age for Artificial Intelligence. The world is becoming increasingly automated and wired together. This also increases the opportunities for AI to help people and commerce. Almost every sub field of AI had now been used in substantial applications. Some of the fields highlighted in this publication are: CBR Technology; Model Based Systems; Data Mining and Natural Language Techniques. Not only does this publication show the activities, capabilities and accomplishments of the sub fields, it also focuses on what is happening across the field as a whole.
