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Renal Fibrosis: Mechanisms and Therapies
This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some...
Immune Landscape of Kidney Pathology
Topic Editor Dr. Patrick Tang holds patents related to anticancer therapy and diabetic prevention. All other Topic Editors declare no competing interests with regards to the Research Topic.
Advances in Mechanisms of Renal Fibrosis
Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis.
The Writing of Official History Under the T'ang
This book describes the selection, processing and editing of material for an authorized history of the T'ang.
Olympic Dreams
Already the world has seen the political, economic, and cultural significance of hosting the 2008 Olympics in Beijing—in policies instituted and altered, positions softened, projects undertaken. But will the Olympics make a lasting difference? This book approaches questions about the nature and future of China through the lens of sports—particularly as sports finds its utmost international expression in the Olympics.
The Mongol Empire and its Legacy
The Mongol empire was founded early in the 13th century by Chinggis Khan and within the span of two generations embraced most of Asia, becoming the largest land-based state in history. The united empire lasted only until around 1260, but the major successor states continued on in the Middle East, present day Russia, Central Asia and China for generations, leaving a lasting impact - much of which was far from negative - on these areas and their peoples. The papers in this volume present new perspectives on the establishment of the Mongol empire, Mongol rule in the eastern Islamic world, Central Asia and China, and the legacy of this rule. The various authors approach these subjects from the view of political, military, social, cultural and intellectual history. This publication has also been published in paperback, please click here for details.
Science and Civilisation in China, Part 13, Mining
The fifth volume of Dr Needham's immense undertaking covers the subjects of chemistry and chemical technology. This, the thirteenth part of the volume, is the first history of Chinese mining to appear in a western language. Covering from the Neolithic period to the present day it deals with the full range of Chinese mining from copper to mercury, arsenic to coal and a large number of other minerals and materials. The author draws extensively not only on written sources but also on archaeological remains, and observation of traditional techniques still in use. The interrelationship between Chinese mining and the social, economic and political conditions in which it took place is examined, and leads the author to conclude that these extraneous factors were probably more important in determining how mining was carried out than technological progress.
