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Individualized Drug Therapy for Patients
Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose. The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by interna...
Total Marrow Irradiation
This book, written by a team of international experts, concisely reviews the rationale and clinical application of image-guided total marrow irradiation, a rapidly emerging area in radiation oncology and hematopoietic cell transplantation. The aim is to provide the practicing radiation oncologist, hematologist, medical physicist, and bone marrow transplant researcher with a fundamental understanding of key aspects and an appreciation of the increasing significance of total marrow irradiation as conditioning for bone marrow transplantation. Detailed attention is paid to the impacts of recent advances in radiation therapy technology, functional PET and MRI, and understanding of the response of...
Encyclopedia of Molecular Pharmacology
An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
The Auditory Cortex
Understanding human hearing is not only a scientific challenge but also a problem of growing social and political importance, given the steadily increasing numbers of people with hearing deficits or even deafness. This book is about the highest level of hearing in humans and other mammals. It brings together studies of both humans and animals thereby giving a more profound understanding of the concepts, approaches, techniques, and knowledge of the auditory cortex. All of the most up-to-date procedures of non-invasive imaging are employed in the research that is described.
Adipokines 2.0
Once viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and fasting affect adipocyte health and accordingly their secretome. Different adipose tissue deposits exist and they vary in cellular composition and function. The evidence is strong of a role of adipokines in cancer, reproductive function, neurological diseases, cardiovascular diseases ,and rheumatoid arthritis. Adipokines are considered useful biomarkers for adipose tissue and metabolic health, an...
Inflammation and Lung Cancer
In recent years there have been various discoveries connecting inflammation and lung cancer and clearly there is growing interest in this area of cancer research. The link between unresolved inflammation and cancer has been well established with estimates that 15% of cancer deaths are inflammation‐related. Evidence for this link includes the following: a) some inflammatory diseases are associated with increased risk of cancer development; b) inflammatory mediators are present surrounding and within most tumors; c) overexpression of inflammatory cytokines increases cancer development and progression in murine studies; d) inhibition of inflammatory mediators decreases cancer development and ...
Data and Applications Security and Privacy XXXIV
This book constitutes the refereed proceedings of the 34th Annual IFIP WG 11.3 Conference on Data and Applications Security and Privacy, DBSec 2020, held in Regensburg, Germany, in June 2020.* The 14 full papers and 8 short papers presented were carefully reviewed and selected from 39 submissions. The papers present high-quality original research from academia, industry, and government on theoretical and practical aspects of information security. They are organized in topical sections named network and cyber-physical systems security; information flow and access control; privacy-preserving computation; visualization and analytics for security; spatial systems and crowdsourcing security; and secure outsourcing and privacy. *The conference was held virtually due to the COVID-19 pandemic.
Family Power
Explains why successful states and empires have developed by fostering collaboration between families and dynasties, and the state.
pHealth 2019
Smart mobile systems like micro-systems, smart textiles and implants and sensor-controlled medical devices, together with related networks and cloud services, are important enablers for telemedicine and pervasive health to become the next generation of health services. Social media and gamification have added further to pHealth as an ecosystem. This book presents the proceedings of pHealth 2019, the 16th in a series of international conferences on personalized health, held in Genoa, Italy, from 10 – 12 June 2019. The book includes 1 keynote, 2 of 4 invited talks, 36 oral presentations and 7 poster presentations from a total of 141 international authors. All submissions were critically revi...
Why Narratives of History Matter
Based on a comparative study of Serbia and Croatia, this book investigates the role of narratives in the integration process of candidate countries into the European Union (EU). It develops an original model in order to analyse the structure and political use of narratives. Its novelty consists in integrating the concept of topoi and other elements of literature studies that enable a fine-grained and yet still transferable approach to narratives. I argue that narratives influence the conditions for possible political action by delineating the range of possible and desirable forms of behaviour. This study's empirical research mainly consists of a discourse analysis of political documents, including parliamentary debates, political speeches and interviews with experts. The author is a political scientist who pursued her PhD at the Bremen International Graduate School of Social Sciences (BIGSSS) and is now working as a project manager at Steinbeis-Europa-Zentrum in Karlsruhe.
