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This book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approaches to biomarker development are important as both prognostic and predictive tools. The final part consists of personalized treatment approaches that include preclinical models of pancreatic cancer ...
Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or chronic inflammation, can only be modeled in vivo. Due to its small size, its short reproduction time, and the possibility to introduce specific gen...
GASTROINTESTINAL ONCOLOGY Blends quality research findings with advanced educational techniques in a uniquely comprehensive approach Written and edited by leading international experts in the field, Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach is an indispensable reference for clinicians, medical practitioners, and trainees involved in the investigation, diagnosis, and treatment of esophageal, gastric, intestinal, colonic, hepatobiliary, pancreatic, and other gastrointestinal tumors. Drawing on the most current evidence-based knowledge, this comprehensive resource reflects the current care of GI cancer patients, enabling effective clinical decision making and patient...
This textbook provides a practically applicable resource for understanding the surgical oncology management of pancreatic cancer. It discusses relevant aspects of anatomy and pathophysiology along with the latest diagnostic techniques. Insightful descriptions are then provided detailing how to perform critical surgical procedures when treating these patients. Relevant perioperative management strategies and emerging themes in cancer biology critical to understanding and treating the disease are also described. The need for cross-discipline collaboration to facilitate and enhance innovation within the discipline is reinforced throughout the text. Each chapter presents the relevant current cli...
This handbook details advances in pancreatic cancer research that have a profound and lasting impact on the field. It features the work of authors who are the very best in their respective fields and will have widespread appeal among clinicians, pathologists and basic scientists who are now struggling to understand this complex and rapidly expanding field.
This Research Topic has received financial support from Phillips and Air Liquide.
Arthouse Crime Scenes is the first book to address the relationship between art cinema and crime, contributing to the study of both categories. Case studies are provided of works by celebrated filmmakers including Lucretia Martell, Kleber Mendonça Filho, Bong Joon Ho, Nuri Bilge Ceylan, Hirokazu Koreeda, Jia Zhangke, Andrey Zvyagintsez and Lee Chang-dong. How is crime represented in art cinema? And how can this be understood in the context of global sociopolitical and film-industrial trends? Arthouse crime scenes draw on variable combinations of elements associated with art cinema and crime genres. Crime might be shown or lurk only at the edges. It might be left unresolved or unexplained. C...
In this issue of Surgical Pathology Clinics, guest editor Dr. Aatur D. Singhi brings his considerable expertise to the topic of Pancreatobiliary Neoplastic Pathology. Top experts in the field discuss precursor and malignant neoplasms (with mimics) such as molecular discoveries (e.g., IOPNs), neoadjuvant treatment histopathology (e.g., grading), immunohistochemical biomarkers (e.g., prognostic markers for neuroendocrine tumors), and more. - Contains 13 relevant, practice-oriented topics including the diagnostic challenge of evaluating small biopsies from the pancreatobiliary system; integrating molecular analysis to the pathologic evaluation of pancreatic cysts; the cytomorphologic and molecu...