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Molecular Targeted Radiosensitizers
Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionall...
The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies
Te rapidly changing concepts in radiation oncology with the development of more precise - strumentation for delivery of radiation therapy and a greater emphasis on hypofractionation technologies require a very intimate knowledge of tumor biology and the infuence of various biologic factors on dose distribution within the tumor in terms of homogeneity as well as prev- tion of any late efects on normal tissue surrounding the tumor itself. Not only are these major factors in clinical practice but also the known factors of inhomogeneity of cancer cells, the impact of microenvironment in terms of radiation efect, and host factors make it mandatory to design therapeutic strategies to improve the o...
Cell Adhesion and Cytoskeletal Molecules in Metastasis
This volume highlights the expression of specific adhesion molecules within human cancer tissues. It details the expression signatures from published DNA microarray and immunohistochemistry studies. Coverage discusses the concept that the alteration of specific adhesion molecules influence the cancer migration ability and cancer damage responses, both features are essential for the survival of an invading tumor cell.
Iris
It is London in the 1950s and early 60s. The gambling clubs, private dining rooms, corrupt politicians and gangsters who run Mayfair as well as the East End had never had it so good . . . Iris wasn't quite a call girl . . . she never took any money for that. But she didn't mind accepting a white fiver for the cab fare back to the dismal family flat, or little gifts, or champagne in heady and glamorous restaurants. She was living very dangerously, trading in ignorance and beauty - though not without a certain street savvy. But then she was plunged, with repugnant violence, into a world of seedy manipulation existing beneath the surface of London society. And innocence and ignorance suddenly become outdated luxuries . . . Acute social observation combines with a tender story of love and innocence in Jean Marsh's powerful novel. 'A delightful London-in-the-Fifties novel' Tim Rice, Daily Telegraph
The Iris Trilogy: Memoirs of Iris Murdoch
Dame Iris Murdoch (1919-1999) was one of the greatest British novelists and philosophers of the twentieth century. She read philosophy at Oxford where she met and later married John Bayley, a literary critic and fellow novelist. So began a forty-year, intense and unconventional but happy marriage, detailed in the classic bestselling memoir Iris. Despite Iris’ extramarital affairs with men and women throughout their long marriage - which John always suspected - their bond was unbreakable, and his memoir beautifully captures their child-like moments of bliss: walking in forests, swimming together in streams, and sharing hot cups of coffee on crisp mornings. These are touching but poignant st...
A Word Child
Hilary Burde, saved by education from a delinquent childhood, cheated out of Oxford by a tragic love tangle, cherishes his obsessive guilt and disappointment in a dull, orderly civil service job. When the man whom he has harmed and betrayed reappears as head of his department, Hilary hopes for forgiveness, even for redemption and a new life, but finds himself haunted by a ghostly repetition.
The Book of Iris
"Brilliant, beautiful, difficult and doomed, Iris Wilkinson (known as the writer Robin Hyde) led a short, tumultuous and incredibly productive life. Here her story is told for the first time in a dramatic and deeply moving narrative. Researched by both authors from 1965 to 1971, it was written in a first draft by Iris Wilkinson's friend, Gloria Rawlinson; since Rawlinson's death in 1995 it has been revised and completed by Derek Challis, Wilkinson's son. It includes appalling accounts of hidden pregnancies, harsh experience as a solo mother, dependence on drugs, intimate acquaintance with sexism and poverty, mental breakdown, and a perilous trip to China in wartime. There are deep friendships and hurtful betrayals. Always there is a dedicated and determined commitment to writing. ..."--Jacket.
Iris Has Free Time
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Iris
Iris captures the relationship of two brilliant intellectuals - Iris Murdoch and John Bayley - both determinedly unworldly and yet utterly devoted to each other. The book includes the complete shooting script and interviews with John Bayley and members of the film's cast.
