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Molecular Cardiology
The aim of Molecular Cardiology: Methods and Protocols is to document state-of-the-art molecular and genetic techniques in the area of cardiology. These modern approaches enable researchers to readily study heart diseases at the molecular level and will promote the development of new therapeutic str- egies. Methods for genetic dissection, signal transduction, and microarray analysis are excellent tools for the study of the molecular mechanisms of cardiovascular diseases. Protocols for transgenesis take advantage of recent advances in many areas of molecular and cell biology. Transgenic models of heart diseases (cardiac hypertrophy, cardiac dysfunction, and so on. ) are powerful tools for the...
Control of the Cardiovascular and Respiratory Systems in Health and Disease
On April 8-9, 1994, a symposium entitled Control of the Cardiovascular and Respiratory Systems in Health and Disease was held at the University of California Davis Medical Center in Sacramento. The purpose of this symposium was to honor the careers of Professors Hazel M. and John C. G. Coleridge. Participants in this symposium came from throughout the world. Their attendance at the symposium was a symbol of great respect and affection for the honorees. The Professors Coleridge have made many important contribu tions to the scientific literature concerning neural control of the cardiovascular and respira tory systems. In addition, they have made remarkable contributions to the lives of other ...
Stage B, a Pre-cursor of Heart Failure, An Issue of Heart Failure Clinics
In the joint American College of Cardiology /American Heart Association classification system, Stage B heart failure refers to patients with structural heart disease but no symptoms of heart failure. Preventing progression of heart failure in Stage B patients is a central concern to heart failure specialists, so two issues have been devoted to this topic. Part I focuses on an understanding of structural heart disease and the factors that cause progression from risk of heart failure to development of structural changes.
Function of Renal Sympathetic Nerves
Sympathetic overactivity is associated with the development of hypertension. Renal denervation (RDN) prevents or delays hypertension in a variety of animal models, which laid the groundwork for the introduction of RDN as a clinical therapy in humans. In 2007, a novel, minimally invasive RDN ablation catheter was first trialled in hypertensive patients, with a 93% success rate of lowering blood pressure for at least three years post-RDN. However, a large scale, sham-controlled clinical trial (Symplicity HTN -3) failed to show reductions in BP greater than sham. The aim of this research topic was to evaluate the efficacy and safety of RDN, to explore the contribution of both afferent and efferent renal nerve activity to hypertension and non-hypertension disorders, and to stimulate future research to better understand the function of the renal nerves and the effects of RDN by highlighting gaps in knowledge.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
