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The Liver
Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries ...
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Meeting the Nation's Needs for Biomedical and Behavioral Scientists
On May 3, 1993, the National Research Council's (NRC) Committee on National Needs for Biomedical and Behavioral Research Personnel convened a public hearing to gather the views of colleagues on the future direction of the National Research Service Awards (NRSA) program. In preparation for the hearing, the committee formulated a set of questions to be addressed by respondents and consulted with the staff of the National Institutes of Health in compiling a list of individuals and organizations to whom a letter soliciting a response to those questions could be sent. (See Appendix A.) A letter posing the following four questions was sent to over 1,000 individuals: What is the most significant ch...
Liver Diseases in Infancy and Childhood
For almost four decades the Josiah Macy, Jr. Foundation has been con vening conferences relating to medicine, medical education, and health care in their broadest contexts. During the 1940s and 1950s the conferences focused on biomedical research, which was at that time in its golden age in the United States. As medical care and medical education ascended in importance, since the mid-1960s the conferences have been largely con centrated on topics in these fields. The Macy Foundation also fosters international conferences, and a major effort in recent years has been a rewarding collaboration with France's most distinguished medical statesman, Professor Robert Debre, and the Inter national Chi...
Toxicology of Glutathione Transferases
Since the discovery of Glutathione S-Transferase (GST) or Glutathione transferase, studies have probed important questions about its pharmacological and physiological significance. Toxicology of Glutathione Transferases is the only text that details the methods used in GST research. With chapters written by experts who have been involved in
The ABC Transporters of Human Physiology and Disease
ATP Binding Cassette (ABC) transporters are a family of integral membrane proteins that are likely to be represented in all the cells of all species of archaea, eubacteria and eukaryota. The vast majority of these proteins control the transport of molecules (from small hydrophilic ions to lipids and proteins) across cellular membranes. The human genome encodes 48 ABC transporters and most have been shown to underlie one or more human diseases. This book that brings together state-of-the-art knowledge on proteins in one volume will provide students, professors and medical professionals with a background to the human ABC transporters that are known to be relevant to diseases. Each of the 14 chapters is written by a leading researcher in the field and includes contributions from Joe Bryan and Lydia Aguilar-Bryan, Kazu Ueda, Jack Riordan and Robert Tamp. The genetics, structure and function of the proteins, and the future direction of research including the implications for human health are discussed in depth.
Microsomes and Drug Oxidations
Microsomes and Drug Oxidations documents the proceedings of symposium on microsomes and drug oxidations held at Bethesda, Maryland, 16-17 February 1968. The theme of the symposium centered on the morphology of the liver endoplasmic reticulum, the localization of enzyme systems, the mechanisms for regulating enzyme activity, and the mechanisms of enzyme action. The results of this symposium presented in this book illustrate the complexity of the enzyme systems under investigation and the multiplicity of the variables altering their function. It is hoped the information presented will serve as a stimulus to other investigators in the elucidation of these problems. The book contains 27 papers organized into four parts. The papers in Part I examine the morphological and biochemical characteristics of microsomes. Part II presents studies on electron transfer components. Part III examines alterations of microsomal enzymes while Part IV focuses on drugs and protein synthesis.
Metabolic Effects of Gonadal Hormones and Contraceptive Steroids
The Center for Population Research of the National Institute of Child Health and Human Development began operations in August 1968 and is engaged in research dealing with health-related popula tion problems. We organize and support projects for the develop ment of new contraceptives and in the broad field of population research in the social sciences o The Center also supports a variety of projects dealing with the mechanism of action and medical effects of contraceptives now in use, particularly oral contraceptives and intrauterine devices. These studies were initiated several years ago at the specific direction of Congresso We were pleased, therefore, with the opportunity to help organize ...
