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No início do séc. XVI, a expansão portuguesa avança sobre as praças mouras do norte de África, conquistando importantes posições do inimigo. Arzila, grandiosa praça costeira, recebe então um novo capitão, o Conde de Redondo, a quem o Rei D. João III, anos mais tarde, concedeu grandes louvores pelos seus serviços. Mas como conseguiu este conde resistir aos cercos de um inimigo muito mais numeroso e ainda tomar posições pelo deserto fora? A razão ainda hoje é um mistério, mas rezam as rónicas que o conde gozava de boas relações com um alcaide mouro que entrava sorrateiramente na praça portuguesa. Com base neste fragmento verdadeiro da História de Portugal, Pedro Torres desenha uma ficção que revela as motivações das misteriosas visitas, o jogo perturbante de paixões e intrigas por detrás das impossíveis conquistas portuguesas. Um jogo doce, elaborado pelas mãos de uma condessa portuguesa, na terra violenta e sensual dos Xarifes...
This paper studies the credibility of the Venezuela crawling-band exchange rate regime during the period July, 1996 - February, 2002. We show that, introducing some modifications, the credibility analysis widely applied to target zone regimes can also be used in studying the credibility of crawling-band regimes. In analyzing the credibility of the Venezuela crawling band, first we use the so-called simple credibility tests developed by Svensson (1991). Additionally, we estimate the expected rate of realignment using the drift-adjustment method. Both the credibility tests and the drift-adjustment method give similar results, showing that the crawling-band system was highly credible during the period.
This book has been made possible by the contributions of leading scientists and clinicians from upcoming and interdisciplinary fields of research concerning the molecular and clinical features of insulin resistance. Multiple metabolic disturbances associated with Insulin Resistance include inflammatory cytokines, adipokines, endothelial dysfunction, tissue-specific defects in insulin action and signaling, oxidative stress, ectopic lipid deposition, and disordered neuroregulation. This book aims to encourage scientists and physicians - working separately on various aspects of Insulin resistance and metabolic syndrome for early detection of the first signs indicating the onset of a metabolic misbalance in order to prevent the consecutive cascades which lead to metabolic syndrome, resulting in the so-called diseases of modern civilization - cancer, diabetes and hypertension.
Covers receipts and expenditures of appropriations and other funds.
Includes entries for maps and atlases.
Celiac disease, as an autoimmune disorder, is a disease which appears in sensing and immune reaction responses to gluten. It has been confirmed that both genetic and environmental factors are involved. CD is strongly associated with the HLA alleles DQB1*02 (serological DQ2) or DQB1*0302 (serological DQ8). These HLA alleles are necessary but not sufficient for the development of CD and non-HLA risk genes also contribute to disease susceptibility. Several studies have identified linkage or association of CD with the 2q33 locus, a region harboring the candidate genes CD28, CTLA4 and ICOS, important immune checkpoints regulators of T-cell activity. Immune checkpoints are crucial to maintain self-tolerance and protect self-tissue from damage during an ongoing immune response.