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Hybrid Biomolecular Modeling
Models of biomolecular structure and dynamics are often obtained by combining simulation or prediction approaches (e.g., comparative modeling, Molecular Dynamics (MD) simulations, Normal Mode Analysis (NMA), etc.) with experimental approaches (e.g., Nuclear Magnetic Resonance (NMR), X-ray crystallography, Small-Angle X-ray Scattering (SAXS), Electron Microscopy (EM), etc.). Such hybrid modeling extends the capabilities of experimental techniques, by enriching structural information and facilitating dynamics studies of biomolecules. This eBook contains articles on methodological developments, applications, and challenges of hybrid biomolecular modeling that have been collected in the framework of the Frontiers Research Topic entitled “Hybrid Biomolecular Modeling”.
The Uteroglobin/Clara Cell Protein Family
The discovery of this family of proteins three decades ago launched a broad range of research effort that now reaches across many potential applications in human reproductive biology, inflammatory diseases, endocrinology, and in oncology. These proceedings papers extend the new function research possibilities inherent in the structure of this steroid-inducible, multifunctional secreted protein, and in the UG-bioactive-derived peptides. An opening overview of the UG family focuses on mammaglobin and its implications with human breast cancer; the sequence/structure sections review applications of antiflammin responses from its peptide. Other sections present new research on regulation of uteroglobin genes by cytokines and hormones; and clinical applications for renal diseases, in targeting gene therapy in pulmonary disease. Together, these developments raise the possibility of cytokine/chemokine-like functions that play important roles in major public health problems. A consensus of nomenclature for Uteroglobin/Clara Cell 10kDa family of proteins is also advanced as a step to coordinating new areas of research for these promising proteins and receptors.
Steroid Hormone Receptors
The molecular mechanisms and gene expression pathways are thoroughly covered in this exceptional volume. The reviews are written by the field's top investigators, yet they are easy to read for students and researchers alike. Clinicians will be interested in the chapters which cover the molecular and biological aspects of disease. Molecular and cell biologists, biochemists, endocrinologists, and pharmaceutical researchers will all benefit from this comprehensive volume.
Visualizing Biological Information
Biological data of all kinds is proliferating at an incredible rate. If humans attempt to read such data in the form of numbers and letters, they will take in the information at a snail's pace. If the information is rendered graphically, however, human analysts can assimilate it and gain insight at a much faster rate. The emphasis of this book is on the graphic representation of information-containing sequences such as DNA and amino acid sequences in order to help the human analyst find interesting and biologically relevant patterns. The editor's goal is to make this voyage through molecular biology, genetics and computer graphics as accessible to a broad audience as possible, with the inclusion of glossaries at the end of most chapters and program outlines where applicable. The book will be of most interest to biologists and computer scientists and the various large reference lists should be of interest to beginners and advanced students of biology, graphic art and computer science. Contributors have sought to find pattern and meaning in the cacophony of genetic and protein sequence data using unusual computer graphics and musical techniques.
Veterinary Vaccines
Vaccines have historically been considered to be the most cost-effective method for preventing communicable diseases. It was a vaccine that enabled global eradication of the dreaded disease smallpox. Mass immunization of children forms the anchor of the strategy of the World Health Organization (WHO) to attain "health for all" status by the year 2000. Vaccinology is undergoing a dimensional change with the advances that have taken place in immunology and genetic engineering. Vaccines that confer short or inadequate immunity or that have side effects are being replaced by better vaccines. New vaccines are being developed for a variety of maladies. Monoclonal antibodies and T cell clones have ...
Rethinking Hypothyroidism
"A scientist, physician, and former president of the American Thyroid Association explains why the standard treatment for hypothyroidism fails many patients and calls for alternatives. The thyroid is a small gland located in your neck, right above the front of your shirt collar. It is shaped like a butterfly and weighs less than an ounce, but it is hugely important. Patients with hypothyroidism-the inability to produce the needed amounts of thyroid hormones-may experience fatigue, sluggishness, and confusion, and they may have issues with their skin, hair, and weight. As hypothyroid patients typically have low levels of thyroid hormones in circulation, treatment is aimed at bringing these le...
The Tangled Tree
In this New York Times bestseller and longlist nominee for the National Book Award, “our greatest living chronicler of the natural world” (The New York Times), David Quammen explains how recent discoveries in molecular biology affect our understanding of evolution and life’s history. In the mid-1970s, scientists began using DNA sequences to reexamine the history of all life. Perhaps the most startling discovery to come out of this new field—the study of life’s diversity and relatedness at the molecular level—is horizontal gene transfer (HGT), or the movement of genes across species lines. It turns out that HGT has been widespread and important; we now know that roughly eight perc...
The Retroviridae
The books in this acclaimed series are the most detailed, up-to-date accounts of the field available. Volume 3 explores the oncogenic potential shared by retroviruses of different species, the widespread presence of retrovirues in nature, and the role of retroviruses in normal development and pathogenesis.
An Interplay of Cellular and Molecular Components of Immunology
Our immune system defends us against infection by employing multiple lines of defense. The relevance of the immune response in human health, disease prevention, and vaccinations becomes evident when the immune system is compromised as in the case of pathogenic infections or autoimmune diseases. The reader will gain a fundamental understanding of the essential principles of immunology, such as how our immune system recognizes/fights infectious agents, how our body differentiates between foreign and self-cells/molecules, and how the memory from previous infections aids in a faster and more effective immune response. The book is divided into 17 chapters, providing an overview of the immune syst...
