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The New York Times bestselling, authoritative account of the life of Charles Manson, filled with surprising new information and previously unpublished photographs: “A riveting, almost Dickensian narrative…four stars” (People). More than forty years ago Charles Manson and his mostly female commune killed nine people, among them the pregnant actress Sharon Tate. It was the culmination of a criminal career that author Jeff Guinn traces back to Manson’s childhood. Guinn interviewed Manson’s sister and cousin, neither of whom had ever previously cooperated with an author. Childhood friends, cellmates, and even some members of the Manson family have provided new information about Manson...
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The efficacy of immunotherapeutic approaches in the treatment of different cancer types is becoming increasingly obvious, and immunotherapies in cancer treatment have experienced a significant breakthrough in the last few years. Immunotherapy encompasses several diverse treatment approaches, each of which has a distinct mechanism of action, and all of which are designed to boost or restore immune function in some manner. Consequently, T cell activating immunotherapeutic approaches like immune checkpoint inhibition, chimeric antigen receptor T cells (CARs), or bi-specific T cell activating antibodies are becoming increasingly important treatment strategies in different solid tumor types as we...