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Anxiety disorders have long been a research subject for scientists in different areas of inquiry, and the particular role of serotonin – the neurotransmitter which has probably most captured the imagination of laymen and academics alike – is as elusive as the clinical aspects of serotonergic medications. Why are drugs acting at certain serotonin receptors efficacious against generalized anxiety disorder, but not panic disorder? Why is the inverse true for monoamine oxidase inhibitors? These clinically relevant issues are clarified by the neurochemical, anatomical and physiological organization of the serotonergic system. In this book, the author summarizes the latest findings regarding t...
The papers in this volume were presented at the NATO Advanced Study Institute held in Porto Novo, Portugal, August 26 - September 8, 1990. The Institute has been able to cover a wide spectrum of the Theoretical and Computational Models for organic molecules and organic reactions, ranging from the ab initio to the more empirical approaches, in the tradition established in the previous Institutes at S. Feliu de Guixols (Spain) and Altinoluk (Turkey). The continuity with this work was achieved by inviting half of the lecturers present in those meetings. But other important subjects were also covered at Porto Novo by new lecturers, both from universities and the industry. Molecular Mechanics, Pr...
Animal models of neuro- and psychopathological states in humans are an indispensable part of both experimental neurology and biological psychiatry. Written by a team of experts, this book provides an up-to-date detailed overview of the current approaches to the design of viable animal models for eight prominent neuropsychiatric diseases. The book is specifically written with the research-oriented reader in mind — both in academia and the pharmaceutical industry. It contains first-hand information on how to design viable animal models for Alzheimer's disease, epilepsy, Huntington's disease, Parkinson's disease, addiction, depression, fear and anxiety, and schizophrenia. Each chapter also critically discusses the limitations of the animal experimental approach towards an understanding of human neuropsychiatric disorders.The book is an essential source of reference for researchers who seek to successfully continue and elaborate the experimental work that will finally lead to a better understanding of the neurobiological basis of the diseases, as well as to an improvement of both diagnosis and therapy.
Contains the list of accessions to the library, formerly (1894-1909) issued quarterly in its series of "Bulletins."
Fatigue in Additive Manufactured Metals provides a brief overview of the fundamental mechanics involved in metal fatigue and fracture, assesses the unique properties of additive manufactured metals, and provides an in-depth exploration of how and why fatigue occurs in additive manufactured metals. Additional sections cover solutions for preventing it, best-practice design methods, and more. The book recommends cutting-edge evidence-based approaches for designing longer lasting additive manufactured metals, discusses the latest trends in the field and the various aspects of low cycle fatigue, and looks at both post-treatment and manufacturing process-based solutions. By providing internationa...
Organized by the French Speaking Society for Study and Research on Essential Trace Elements (SFERETE), the Fifth International Congress on Trace Elements in Medicine and Biology "Therapeutic Uses of Trace Elements" was held February 4-7. 1996, in Meribel (Savoy, France). This resort is situated in the heart of the Three Valleys domain, at the gate way of the beautiful Vanoise National Park. More than 250 participants covering six conti nents attended the meeting. This volume contains the text of plenary lectures and of several oral and poster communications. Trace element deficiencies are not only encountered in developing countries or during malnutrition. Subclinical features are also observed in developed societies where they consti tute a background for an impressive number of pathological states. Preventive and curative treatments with commercial products are often prescribed without reliable studies about their clinical interest or potential efficiency. By contrast empirical approaches such as the catalytic therapy, nutritional and pharmacological aspects of trace elements were emphasized on a sci entific basis to favor their rational therapeutic use.
Covers such subjects as: Ab initio and Density functional theory calculations of electric polarizability and hyperpolarizability, intermolecular forces, aromaticity, electric properties of solvated molecules, NLO materials, Raman intensities, polarizability of metal and semiconductor clusters, relativistic effects on electric properties, and more.