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The islets of Langerhans, the primary source of hormone production in the pancreas, have been the focus of research into the nature of diabetes for decades. In recent years, the molecular biology of this multiendocrine organ has been intensively investigated, with a corresponding increase in our understanding of the normal and pathological functioning of islet cells.
This book is the first to combine computational material science and modeling of molecular solid states for pharmaceutical industry applications. • Provides descriptive and applied state-of-the-art computational approaches and workflows to guide pharmaceutical solid state chemistry experiments and to support/troubleshoot API solid state selection • Includes real industrial case examples related to application of modeling methods in problem solving • Useful as a supplementary reference/text for undergraduate, graduate and postgraduate students in computational chemistry, pharmaceutical and biotech sciences, and materials science
Thoroughly updated, this essential reference source introduces scholars to the study of organized labor on the international as well as national level. Contains 400 entries describing the labor movements in countries around the world, and the important people, organizations, ideas, and political parties involved in organized labor. Includes a summary list of past and present international labor leaders, lists of global union federations and the affiliated organizations of major national labor federations, and analytical lists of the membership of the International Confederation of Free Trade Unions.
A special issue of Molecular and Cellular Biochemistry comprised of 42 papers selected from an August 1996 conference in Kenora, Ontario, Canada. They cover vascular changes in health and disease, cardiac mechanisms in health, sub-cellular changes in cardiomyopathies and heart failure, and cellular biochemistry in non-cardiovascular tissues. Among the specific topics are studies on hepatic injury and anti-oxidant enzyme activities in rat subcellular organelles following in vivo ischemia and reperfusion, cardiomyopathies and mitochondrial DNA mutations, the contributions of increased efficiency and capacity of protein synthesis to rapid cardiac growth, and the migration of heterogeneous cell populations from the vessel wall in cultures of coronary artery smooth muscles. No subject index. Annotation copyrighted by Book News, Inc., Portland, OR
FROM THE PREFACE:The original purpose of the First Edition of Physiology of the Gastrointestinal Tractto collect in one set of volumes the most current and comprehensive knowledge in our fieldwas also the driving force for the Fourth Edition. The explosion of information at the cellular level, made possible in part by the continued emergence of powerful molecular and cellular techniques, has resulted in a greater degree of revision than that of any other edition. The first section, now titled "Basic Cell Physiology and Growth of the Gl Tract" contains numerous new chapters on topics such as transcriptional regulation, signaling networks in development, apoptosis, and mechanisms in malignanci...
There are five main subject areas in this volume in the series on medicinal chemistry. The first is a review of the understanding of Alzheimer's disease and the development of drugs for its treatment; the second, looking at recent efforts in modifying a naturally occuring anticancer (campothecin) for chemotherapy; the third covers the problem of getting a drug to a specific site within the context of phosphates and phosphonates; a survey of sterilization using aldehydes for the destruction of microbes both inside and outside the human body is reviewed in the fourth; and the last chapter is an account of the progress made in the biologically active enantiomer for complex synthetic asymmetric drug molecules.
This revised and updated text on diabetes mellitus encompasses recent advances in molecular and cellular findings, and provides new therapeutic modalities for the disease. Adhering to the successful format of the first edition, the book is divided into ten distinct sections, each containing individual chapters that progress from basic mechanisms to physiology to therapeutic. It covers the complications of diabetes at both the basic and clinical levels.