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Covalent Catalysis by Enzymes
Some years ago one of my students and I reported that the acetate kinase reaction is mediated by a phosphorylated form of the enzyme [R. S. Anthony and L. B. Spector, lBe 245, 6739 (1970)]. The reversible reaction between ATP and acetate to give acetyl phosphate and ADP had hitherto been thought to proceed by direct transfer of a phosphoryl group from A TP to acetate in a single-displacement reaction. But now it became clear that acetate kinase was one of that substantial number of enzymes whose mech anism is that of the double displacement. For some reason, I began to wonder about the possibility that all enzymes, like acetate kinase, are double displacement enzymes, and do their work by co...
Organic Reaction Mechanisms 1978
The only book series to summarize the latest progress on organic reaction mechanisms, Organic Reaction Mechanisms, 1978 surveys the development in understanding of the main classes of organic reaction mechanisms reported in the primary scientific literature in 1978. The 14th annual volume in this highly successful series highlights mechanisms of stereo-specific reactions. Reviews are compiled by a team of experienced editors and authors, allowing advanced undergraduates, graduate students, postdocs, and chemists to rely on the volume's continuing quality of selection and presentation.
Practical Cardiovascular Hemodynamics
Elias Hanna and D. Luke Glancy provide an in-depth understanding of waveforms and tracings seen in varous disease states as well as pathophysiology behind those findings. Practical issues that are rarely discussed or focused upon in textbooks are highlighted in this book with detailed waveform analysis. Caveats in the hemodynamic assessment of valvular diseases, constriciion, tamponade, pulmonary hypertension, shunt pathology, and right and left ventricular failure are provided. This book also provides case-based and tracing-based quizzes. The reader wil learn to identify disease states and waveform subtleties from single tracings or from case studies. The reader will take the initiative to interpret tracings, understand notches, artifacts, and formulate a diagnosis. This book will feature: Complete presentation of basic and advanced hemodynamics. Numerous case studies allow the reader to learn real-life application of hemodynamic data in clinical decision-making. Quizzes and explanations provides the reader with self-assessment and problem solving skills Over 300 illustrations with detailed discussion.
Textbook of Cardiovascular Intervention
The field of interventional cardiology and interventional vascular medicine now comprises the dominant diagnostic and therapeutic field within cardiovascular medicine, and continues to grow in terms of patients managed and physicians trained. The Textbook of Cardiovascular Intervention is intended to provide a modern, comprehensive and practical text on interventional cardiology for the current, rapidly evolving practice environment. It is written by a group of worldwide experts in the field and will appeal to fellows, residents and physicians in cardiology, interventional cardiology, cardiothoracic and vascular surgery, vascular and endovascular medicine, neurointerventional radiology and surgery, emergency medicine and intensive care.
5th European Conference of the International Federation for Medical and Biological Engineering 14 - 18 September 2011, Budapest, Hungary
This volume presents the 5th European Conference of the International Federation for Medical and Biological Engineering (EMBEC), held in Budapest, 14-18 September, 2011. The scientific discussion on the conference and in this conference proceedings include the following issues: - Signal & Image Processing - ICT - Clinical Engineering and Applications - Biomechanics and Fluid Biomechanics - Biomaterials and Tissue Repair - Innovations and Nanotechnology - Modeling and Simulation - Education and Professional
Physiological Assessment of Coronary Stenoses and the Microcirculation
Since the introduction of coronary angiography, a key technique in understanding coronary artery disease, a number of paradigms regarding its study and interpretation have taken place. Following an emphasis on improved angiographic and subsequent intracoronary imaging techniques, functional assessment of coronary circulation has demonstrated to have major implications for diagnosis and treatment of coronary artery disease. Fractional flow reserve, a pressure derived index of stenosis severity, constitutes the best example of the current importance of physiological assessment in clinical practice. However, the acceptance of FFR by cardiologists contrasts with important voids in knowledge on t...
Intelligent and Autonomous: Transforming Values in the Face of Technology
This book uses case analyses and industry insights and blends them with forays into philosophy and ethics to conceptualise the mismatch between human values and the values inherent in an increasingly technologized world. Bringing together contributors from the disciplines of law, politics, philosophy, and communication studies, this volume develops an interdisciplinary vocabulary for thinking about the questions and antinomies of human-technology interaction while also resisting any deceptively straightforward synthesis. The topics discussed include the competition over and regulation of technology, the harm induced by autonomous technologies, and the place and role of humans in a world that is undergoing rapid and radical change.
