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By covering the full spectrum of topics relevant to peptidic drugs, this timely handbook serves as an introductory reference for both drug developers and biomedical researchers interested in pharmaceutically active peptides, presenting both the advantages and challenges associated with this molecular class. The first part discusses current approaches to developing pharmaceutically active peptides, including case studies of the use of peptidic drugs in cancer and AIDS therapy. The second part surveys strategies for the development and targeting of peptidic drugs. With its integration of biochemical, pharmaceutical and clinical research, this work reveals the full picture of modern peptide drug research in a single volume, making it an invaluable reference for medicinal chemists, biochemists, biotechnologists, and those in the pharmaceutical and biotechnological industries.
A much-needed reference on survey sampling and its applications that presents the latest advances in the field Seeking to show that sampling theory is a living discipline with a very broad scope, this book examines the modern development of the theory of survey sampling and the foundations of survey sampling. It offers readers a critical approach to the subject and discusses putting theory into practice. It also explores the treatment of non-sampling errors featuring a range of topics from the problems of coverage to the treatment of non-response. In addition, the book includes real examples, applications, and a large set of exercises with solutions. Sampling and Estimation from Finite Popul...
Recent years have witnessed important developments in those areas of the mathematical sciences where the basic model under study is a dynamical system such as a differential equation or control process. Many of these recent advances were made possible by parallel developments in nonlinear and nonsmooth analysis. The latter subjects, in general terms, encompass differential analysis and optimization theory in the absence of traditional linearity, convexity or smoothness assumptions. In the last three decades it has become increasingly recognized that nonlinear and nonsmooth behavior is naturally present and prevalent in dynamical models, and is therefore significant theoretically. This point ...
Over the last few decades, important progresses in the methods of sampling have been achieved. This book draws up an inventory of new methods that can be useful for selecting samples. Forty-six sampling methods are described in the framework of general theory. The algorithms are described rigorously, which allows implementing directly the described methods. This book is aimed at experienced statisticians who are familiar with the theory of survey sampling.
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