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Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors
In 1971, Vane proposed that the mechanism of action of the aspirin-like drugs was through their inhibition of prostaglandin biosynthesis. Since then, there has been intense interest in the interaction between this diverse group of inhibitors and the enzyme known as cyclooxygenase (COX). It exists in two isoforms, COX-l and COX-2 (discovered some 5 years ago). Over the last two decades several new drugs have reached the market based on COX-l enzyme screens. Elucidation of the three-dimensional structure of COX-l has provided a new understanding for the actions of COX inhibitors. The constitutive isoform of COX, COX-l has clear physiological functions. Its activation leads, for instance, to th...
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
The Effect of Diet and Nutrition on Postprandial Metabolism
The postprandial period is the metabolic phase that directly follows the ingestion of a meal. This period is critical to the handling of nutrients to feed the body throughout the whole day but it is also a time of challenge for the body’s metabolism, which has to be flexible and adaptable regarding the quantity and the quality of the nutrient intake. Changes in postprandial metabolism have been considered to be potential early markers in the pathophysiological course, finally leading to an increased risk of disease development. This book aimed to broaden and add to the research on the importance of postprandial metabolism in nutrition. The book includes literature reviews that cover the br...
New Symmetry Principles in Quantum Field Theory
Soon after the discovery of quantum mechanics, group theoretical methods were used extensively in order to exploit rotational symmetry and classify atomic spectra. And until recently it was thought that symmetries in quantum mechanics should be groups. But it is not so. There are more general algebras, equipped with suitable structure, which admit a perfectly conventional interpretation as a symmetry of a quantum mechanical system. In any case, a "trivial representation" of the algebra is defined, and a tensor product of representations. But in contrast with groups, this tensor product needs to be neither commutative nor associative. Quantum groups are special cases, in which associativity i...
Pooling of Patents
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Appendix to hearings
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Handbook of Materials for String Musical Instruments
This book addresses core questions about the role of materials in general and of wood in particular in the construction of string instruments used in the modern symphony orchestra – violins, violas, cellos and basses. Further attention is given to materials for classical guitars, harps, harpsichords and pianos. While some of the approaches discussed are traditional, most of them depend upon new scientific approaches to the study of the structure of materials, such as for example wood cell structure, which is visible only using modern high resolution microscopic techniques. Many examples of modern and classical instruments are examined, together with the relevance of classical techniques fo...
