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Principles and Practice of Clinical Research
The third edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research ...
Nutrition and Critical Care
A complete state-of-the-art manual on nutritional support for ICU patients, the present book, written by internationally renowned specialists, addresses fundamental aspects of the pathophysiological response to injury as well as practical issues of nutritional care. New features include an analysis of gene polymorphism and its possible consequences for the survival of traumatized patients. A better understanding of this process could become a basis for defining new nutritional strategies. Hence the discussion on indications for immune-enhancing diets. Of special interest is the research on copathologies (i.e. obesity) which can change the prognosis of ICU patients who thus require specific nutritional support. Entirely new is the merging of the recommendations of international and national societies (e.g. ASPEN, ESPEN), first realized for this publication. This book is a basic tool for any professional in the field of nutritional care for ICU patients: intensivists, surgeons, pharmacists, dieticians, and PhD students.
The Cardiovascular Adrenergic System
An overview of all the available literature on the various aspects of the regulation of the cardiovascular system`s function and physiology by the adrenergic neurohormonal system, i.e. the catecholamines norepinephrine and epinephrine. Although there are several books describing the adrenergic system`s biology, physiology and pharmacology, and also several excellent books on cardiovascular physiology and pathology, this book focuses exclusively on the interface of these two areas: cardiovascular regulation by the adrenergic system and how it affects cardiovascular diseases and their treatments. Each chapter describe the roles of the adrenergic system first in each cardiovascular cell type (c...
Anti-aging Drugs
Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medicatio...
Stress in Swine
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