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The Superfamily of ras-Related Genes
since the earliest results on the linkage between ras activation and cell transformation appeared a vast amount of additional information has been generated which emphasizes the importance of ras-related genes in membrane trafficking, cell proliferation, differentiation and cancer. These advances led to the development of new strategies for the diagnosis, prognosis and prevention of cancer. Ras-related genes appear to be central to the mechanism of transformation by other oncogenes and therefore constitute a focal point upon which attempts to intervene in the process of carcinogenesis will be concentrated. The present volume contains the contributions to the NATO Advanced Research Workshop o...
The Retroviridae
depth overview of the retrovirus family. I have greatly enjoyed and learned from this experience. Each chapter is an excellent introduction to the topic covered and provides a good foundation for further work in the field. Jay A. Levy University of California School of Medicine San Francisco, California REFERENCES Brown, E. W., Yuhki, N., Packer, C., and O'Brien, S. J., 1994, A lion lentivirus related to feline immunodeficiency virus: Epidemiologic and phylogenetic aspects, ,. Viral. 68:5953-5968. Merza, M., Larsson, E., Steen, M., and Morein, B., 1994, Association of a retrovirus with a wasting condition in the Swedish moose, Virology 202:956-961. Contents Chapter 1 The Human Immunodeficien...
The Search for New Anticancer Drugs
Most of the anti-cancer drugs in use today were discovered by happy accident rather than design, yet the rational design of better anti-cancer drugs remains a cherished goal, and one of the most important challenges facing medical science. This book represents a compilation of views and progress reports which illustrate the diversity of approaches to the problem. Recent research has confirmed the belief that critical genetic changes are at work in cancer cells. The genome, then (DNA in biochemical terms), surely represents a critical target for specific chemotherapy of cancer, and several chapters address the issue of attacking DNA, gene targetting, and the like. Others deal with principles of rational design, exploitation of novel modalities and targets, or the nuts and bolts of antitumour drug testing. While no attempt has been made to provide a comprehensive coverage of this wide-ranging and vitally important subject, the present volume in the series will provide much food for thought.
Biology of Carcinogenesis
There is no shonage of books on cancer. Why publish another? Simply because the subject is important: possibly the most important challenge facing medicine today, and consequently the focus of one of the faslest-growing areas of fundamental biological research. The quest to understand and control cancer is so absorbing that from time 10 time we really need to pause for a moment and try to take stock of the situation. Given the sheer breadth of cancer-related research that is not an easy task. This book, together with its planned successors in the series Cancer Biology and Medicine. represents our attempt to draw back from the bench or the bedside for a moment and take a slightly longer look at what we are doing, what we are trying to do, and where we stand. It is impossible to be comprehensive or even representative of more than a fraction of relevant knowledge. but that is no excuse for not trying to see things in perspective. Accordingly we set out to persuade a number of our colleagues to join us in writing a book which might admit a little fresh air into the confined atmosphere within which we mostly work: a glimpse, perhaps. of fresh vistas.
Advances in Cancer Research
Advances in Cancer Research
Acute Leukemias
This is the third volume in this series on methods of treating acute leukemia. Multiple drug resistance is discussed, along with the use of human granulocyte-macrophage CSF, the role of stem cell factor, and basic aspects of cell biology and pharmakokinetics. There is also a comprehensive section dealing with relapse therapy and postremission therapy. The book thus provides the clinician with guidelines for use in everyday practice.
Environmental Protection of the North Sea
Environmental Protection of the North Sea focuses on measures and initiatives for the protection of the North Sea. The book first discusses the physical features, North Sea resources, and biological considerations. The compilation then takes a look at the distribution of anthropogenic organic compounds in the North Sea, including analytical aspects and reporting format for polychlorinated biphenyls (PCBs); transport of PCB in abiotic phases in rivers, estuaries, and the North Sea; and PCB in biota. The text examines the environmental impacts of organic chemicals. History of pollution; environmental effects of chemicals; effects of chemicals on marine biota; and chemicals of potential concern...
