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First published in 1986 under the editorial direction of Dr. Henry J.M. Barnett, Stroke: Pathophysiology, Diagnosis, and Management continues to provide the dependable, current answers you need to effectively combat the increasing incidence of this disease. Dr. J.P. Mohr, together with new associate editors Philip A. Wolf, James C. Grotta, Michael A. Moskowitz, Marc Mayberg, and Rüdiger von Kummer as well as a multitude of expert contributors from around the world, offer you updated and expanded coverage of mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and...
With the global renewal of interest in PVC, this comprehensive book is well timed. Considering that PVC stabilization is the most important part of its formulation and performance, only four books have ever been published on this subject, and none since the 1980s. This book contains information on: chemical structure; PVC manufacturing technology; morphology; degradation by thermal energy and UV, gamma, and other forms of radiation; mechanodegradation; chemical degradation; analytic methods used in studying degradative and stabilization processes; stabilization; and the effect of PVC and its additives on health, safety, and environment. This is the one authoritative source on this subject.
Microbial carbonates (microbialites) are remarkable sedimentary deposits because they have the longest geological range of any type of biogenic limestones, they form in the greatest range of different sedimentary environments, they oxygenated the Earth’s atmosphere, and they produce and store large volumes of hydrocarbons. This Special Publication provides significant contributions at a pivotal time in our understanding of microbial carbonates, when their economic importance has become established and the results of many research programmes are coming to fruition. It is the first book to focus on the economic aspects of microbialites and in particular the giant pre-salt discoveries offshore Brazil. In addition it contains papers on the processes involved in formation of both modern and ancient microbialites and the diversity of style in microbial carbonate buildups, structures and fabrics in both marine and non-marine settings and throughout the geological record.
Cell and gene therapies have become the third major drug modality in pharmaceutical medicine of the 21st century after low molecular weight and antibody drugs. The gene therapy (GTx) field is rapidly advancing, and yet there are still fundamental scientific questions that remain to be answered. Development of GTx products poses unique challenges and opportunities for drug developers. However, there is lack of a systematic exposition of the GTx product development and the pivotal role of the biostatistician in this process. Development of Gene Therapies: Strategic, Scientific, and Regulatory, and Access Considerations attempts to summarize the current state-of-the-art strategic, scientific, s...
This book offers meaningful insights into an impending challenge for the energy industry, namely the increasing role of asset management amongst the utilities’ core operations. In the aftermath of energy digitalization, power and gas companies will be able to seize asset productivity—through risk-based operation and maintenance—and better balance capital and operational expenditures. By addressing the asset management of both power and gas infrastructures, and by adopting a comprehensive approach—including regulation and business models, as well as a solid technology background—this book offers a unique perspective on the energy utilities’ transformation journey and the road to o...
This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS
This book contains an abundance of numerical analyses based on significant data sets, illustrating the close affiliation between intelligent solutions and future mobility. Which of the prediction models should be applied to improve road safety? How to solve selected issues with assessment of urban roundabouts? What is the future of shared mobility services? How to use spatial data in planning processes related to electromobility implementation? What is the right approach to the problem of road and rail traffic processes? This book provides you with answers to these and many other questions. With regard to the research results discussed and the selected solutions applied, the book primarily a...