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Single-Domain Antibodies: Biology, Engineering and Emerging Applications
  • Language: en
  • Pages: 338

Single-Domain Antibodies: Biology, Engineering and Emerging Applications

Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics.

Therapeutic Exercise for Musculoskeletal Injuries 4th Edition
  • Language: en
  • Pages: 1168

Therapeutic Exercise for Musculoskeletal Injuries 4th Edition

Updated with the latest in contemporary science and peer-reviewed data, Therapeutic Exercise for Musculoskeletal Injuries, Fourth Edition, prepares students for real-world applications while serving as a referential cornerstone for experienced rehabilitation clinicians.

Artificial Intelligence in Medicine
  • Language: en
  • Pages: 551

Artificial Intelligence in Medicine

This book constitutes the refereed proceedings of the 10th Conference on Artificial Intelligence in Medicine in Europe, AIME 2005, held in Aberdeen, UK in July 2005. The 35 revised full papers and 34 revised short papers presented together with 2 invited contributions were carefully reviewed and selected from 148 submissions. The papers are organized in topical sections on temporal representation and reasoning, decision support systems, clinical guidelines and protocols, ontology and terminology, case-based reasoning, signal interpretation, visual mining, computer vision and imaging, knowledge management, machine learning, knowledge discovery, and data mining.

Aristotle's Politics Today
  • Language: en
  • Pages: 176

Aristotle's Politics Today

According to Aristotle, man's essential sociality implies a distinctive conception of politics, one in which all political associations exist for the sake of the moral perfection of human beings. This stands in sharp contrast with the modern view of politics that man is not "by nature" political; rather, man chooses to create political associations for the sake of securing the protection of his life and property. Many political theorists have begun to express doubts about this modern view, calling for a return to Aristotle's vision of a politics that is deeply moral. In Aristotle's Politics Today, distinguished political philosophers representing a diversity of approaches examine the meaning, relevance, and implications of Aristotle's political thought for contemporary social and political theory. The contributors engage a broad range of topics, including Aristotle's views on constitutionalism, the extension of Aristotelian ideas to issues in international relations, the place of Aristotelian virtue in modern democratic politics, and Aristotle's conception of justice.

Commerce Business Daily
  • Language: en
  • Pages: 1634

Commerce Business Daily

  • Type: Book
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  • Published: 2000
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  • Publisher: Unknown

None

Ecological Niches
  • Language: en
  • Pages: 224

Ecological Niches

Why do species live where they live? What determines the abundance and diversity of species in a given area? What role do species play in the functioning of entire ecosystems? All of these questions share a single core concept—the ecological niche. Although the niche concept has fallen into disfavor among ecologists in recent years, Jonathan M. Chase and Mathew A. Leibold argue that the niche is an ideal tool with which to unify disparate research and theoretical approaches in contemporary ecology. Chase and Leibold define the niche as including both what an organism needs from its environment and how that organism's activities shape its environment. Drawing on the theory of consumer-resource interactions, as well as its graphical analysis, they develop a framework for understanding niches that is flexible enough to include a variety of small- and large-scale processes, from resource competition, predation, and stress to community structure, biodiversity, and ecosystem function. Chase and Leibold's synthetic approach will interest ecologists from a wide range of subdisciplines.

Test Reports
  • Language: en

Test Reports

  • Type: Book
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  • Published: Unknown
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  • Publisher: Unknown

None

Aspects of Cameroon English Phonology
  • Language: en
  • Pages: 468

Aspects of Cameroon English Phonology

Cameroon English (CamE) phonology has already developed into a quasi-autonomous system. Thousands of segmental and stress deviations from native English reach, or approximate to a frequency of 100%. Analysed from a generative perspective, the deviations are shown to derive from the fact that certain Received Pronunciation (RP) rules do not apply in CamE while others apply differently, partially or more generally, and still many others are typically Cameroonian. One of the major proposals of the book is the concept of Trilateral Process which consists of RP phonological processes symbolized by a side AA', the restructuring of the RP underlying representation (UR) into a CamE UR by AB and CamE phonological rules by BB'. The concept is applicable to other non-native Englishes.

Islands and Chains
  • Language: en
  • Pages: 242

Islands and Chains

The present work provides a detailed analysis of chain formation and locality conditions imposed on it within the Minimalist Program. It does so by analyzing resumptive strategies in great detail. This study claims that resumptive pronouns and their antecedents are first merged as constituents, and are separated via movement (thus forming instances of discontinuous constituents). Resumptive chains are thus akin to the well-known stranding analysis of quantifier float. A taxonomy of islands is developed that crucially ties barriers for movement to agreement possibilities. The stranding of a resumptive pronoun is shown to limit the role of agreement for the moving element, thereby allowing a chain to be formed across an island.

Handbook of Collective Robotics
  • Language: en
  • Pages: 940

Handbook of Collective Robotics

  • Type: Book
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  • Published: 2013-05-29
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  • Publisher: CRC Press

This book is devoted to mechatronic, chemical, bacteriological, biological, and hybrid systems, utilizing cooperative, networked, swarm, self-organizing, evolutionary and bio-inspired design principles and targeting underwater, ground, air, and space applications. It addresses issues such as open-ended evolution, self-replication, self-development,