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Anti-fibrotic Drug Discovery
Fibrosis is a condition with globally high unmet medical need, and as such is a highly active area of academic and pharmaceutical research covering multiple treatment targets, organs, tissues and therapeutic approaches. Anti-fibrotic Drug Discovery is a single source reference for the latest drug-discovery approaches to tackle fibrosis in various tissues, comprehensively covering recent success and future perspectives on emerging therapeutic intervention points. The book highlights significant pre-clinical and clinical drugs currently being developed globally for this disorder. This book is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver, kidney, heart and lung disease, in which fibrosis plays a key role in pathology.
DNA Repair and Replication
DNA Repair and Replication contains an up-to-date review of general principles of DNA replication and an overview of the multiple pathways involved in DNA repair. Specific DNA repair pathways, including base-excision repair, light-dependent direct reversal of UV-damage, nucleotide-excision repair, transcription-coupled repair, double-strand break repair, and mismatch repair, are each discussed in separate chapters.Selected Contents: - Base Excision Repair - Eukaryotic DNA Mismatch Repair - Double Strand Break Repair - Functions of DNA Polymerases - Somatic Hypermutation: A Mutational Panacea
Futuristic Materials
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DNA Damage Recognition
Stands as the most comprehensive guide to the subject-covering every essential topic related to DNA damage identification and repair. Covering a wide array of topics from bacteria to human cells, this book summarizes recent developments in DNA damage repair and recognition while providing timely reviews on the molecular mechanisms employe
Battery Safety and Abuse Tolerance
Safety of batteries and electrochemical capacitors has taken on more importance for battery manufacturers, government regulators as well as system integrators. Papers in this issue describe all aspects of battery and electrochemical capacitor safety, including new materials and their reactivity, decomposition reactions that generate heat and gas, the role of separators in abuse response and battery pack design.
Physics of Liquid Matter: Modern Problems
These proceedings comprise invited and contributed papers presented at PLMMP-2014, addressing modern problems in the fields of liquids, solutions and confined systems, critical phenomena, as well as colloidal and biological systems. The book focuses on state-of-the-art developments in contemporary physics of liquid matter. The papers presented here are organized into four parts: (i) structure of liquids in confined systems, (ii) phase transitions, supercritical liquids and glasses, (iii) colloids, and (iv) medical and biological aspects and cover the most recent developments in the broader field of liquid state including interdisciplinary problems.
Essential Oils
Over the centuries humans have used essential oils in the most diverse applications, mainly medicinal, and as sources of bioactive molecules. They have been used in different industrial sectors, such as the pharmaceutical and chemical industries, cosmetics and more recently in the food industry. Due to new research in the field of food science and technology, new sources of bioactive compounds have been described, as they have been shown to be a viable alternative for applications in biofilms, nano emulsions, natural antioxidants, control of microorganisms such as fungi, bacteria and protozoa that can be pathological for human health. The use of essential oils in food science and technology ...
Nanostructured Hexagonal Ferrites
Nanostructured Hexagonal Ferrites: Novel Characteristics and Multifunctional Applications presents the latest advances in hexaferrite nanostructures, which offer reliability, stability, and efficiency in a range of advanced applications. The book begins by introducing the structure, characteristics, fabrication, processing, characterization methods, and composites of hexagonal ferrites in detail. Solid-state chemistry and magnetic, magnetoelectric, multiferroic, and dielectric properties are examined. Subsequent chapters then provide in-depth coverage of the preparation of nanohexaferrites with specific properties for target applications, in areas such as magnetic energy storage, high-freque...
Genome Stability and Human Diseases
Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific ge...
