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Fungal pathogens pose an on-going and serious threat for poikilotherms and homeotherms, and can cause a broad spectrum of diseases ranging from innocuous to life-threatening. In addition, long-term exposure to some mycotoxigenic moulds can lead to mycotoxicoses in human and animals. Given the expanding population of immune compromised hosts, the list of fungal opportunists grows longer every year. Moreover, antifungal resistance, drug-related toxicity and our limited arsenal of antifungals have exacerbated the situation. To address these problems, strategies such as the identification of novel targets, use of the structure-activity relationship in rational drug design, development of new for...
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Signal Transduction, 2e, is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction, 2e, serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields. Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention In-depth coverage of nuclear receptors, including steps in isolation of steroid hormones and the discovery of intracellular hormone receptors; tyrosine protein kinases and adaptive immunity; and intracellular calcium Extensive conceptual color artwork to assist with comprehension of key topics Instrumental margin notes highlight milestones in signaling mechanisms
Ancestral Mounds deconstructs earthen mounds and myths in examining their importance in contemporary Native communities. Two centuries of academic scholarship regarding mounds have examined who, what, where, when, and how, but no serious investigations have addressed the basic question, why? Drawing on ethnographic and archaeological studies, Jay Miller explores the wide-ranging themes and variations of mounds, from those built thousands of years ago to contemporary mounds, focusing on Native southeastern and Oklahoma towns. Native peoples continue to build and refurbish mounds each summer as part of their New Year’s celebrations to honor and give thanks for ripening maize and other crops and to offer public atonement. The mound is the heart of the Native community, which is sustained by song, dance, labor, and prayer. The basic purpose of mounds across North America is the same: to serve as a locus where community effort can be engaged in creating a monument of vitality and a safe haven in the volatile world.