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Statistical Methods in Health Disparity Research
  • Language: en
  • Pages: 298

Statistical Methods in Health Disparity Research

  • Type: Book
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  • Published: 2023-07-11
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  • Publisher: CRC Press

• Presents an overview of methods and applications of health disparity estimation • First book to synthesize research in this field in a unified statistical framework • Covers classical approaches, and builds to more modern computational techniques • Includes many worked examples and case studies using real data • Discusses available software for estimation

Statistical Methods in Health Disparity Research
  • Language: en
  • Pages: 341

Statistical Methods in Health Disparity Research

  • Type: Book
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  • Published: 2023-07-11
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  • Publisher: CRC Press

A health disparity refers to a higher burden of illness, injury, disability, or mortality experienced by one group relative to others attributable to multiple factors including socioeconomic status, environmental factors, insufficient access to health care, individual risk factors, and behaviors and inequalities in education. These disparities may be due to many factors including age, income, and race. Statistical Methods in Health Disparity Research will focus on their estimation, ranging from classical approaches including the quantification of a disparity, to more formal modeling, to modern approaches involving more flexible computational approaches. Features: Presents an overview of meth...

Encyclopedia of Medical Decision Making
  • Language: en
  • Pages: 1281

Encyclopedia of Medical Decision Making

  • Type: Book
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  • Published: 2009-08-18
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  • Publisher: SAGE

The Encyclopedia of Medical Decision Making presents state-of-the-art research and ready-to-use facts sorting out findings on medical decision making and their applications.

Mathematical and Statistical Applications in Life Sciences and Engineering
  • Language: en
  • Pages: 374

Mathematical and Statistical Applications in Life Sciences and Engineering

  • Type: Book
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  • Published: 2017-12-06
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  • Publisher: Springer

The book includes articles from eminent international scientists discussing a wide spectrum of topics of current importance in mathematics and statistics and their applications. It presents state-of-the-art material along with a clear and detailed review of the relevant topics and issues concerned. The topics discussed include message transmission, colouring problem, control of stochastic structures and information dynamics, image denoising, life testing and reliability, survival and frailty models, analysis of drought periods, prediction of genomic profiles, competing risks, environmental applications and chronic disease control. It is a valuable resource for researchers and practitioners in the relevant areas of mathematics and statistics.

Value of Information for Healthcare Decision-Making
  • Language: en
  • Pages: 317

Value of Information for Healthcare Decision-Making

  • Type: Book
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  • Published: 2024-02-08
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  • Publisher: CRC Press

Value of Information for Healthcare Decision-Making introduces the concept of Value of Information (VOI) use in health policy decision-making to determine the sensitivity of decisions to assumptions, and to prioritise and design future research. These methods, and their use in cost-effectiveness analysis, are increasingly acknowledged by health technology assessment authorities as vital. Key Features: Provides a comprehensive overview of VOI Simplifies VOI Showcases state-of-the-art techniques for computing VOI Includes R statistical software package Provides results when using VOI methods Uses realistic decision model to illustrate key concepts The primary audience for this book is health economic modellers and researchers, in industry, government, or academia, who wish to perform VOI analysis in health economic evaluations. It is relevant for postgraduate researchers and students in health economics or medical statistics who are required to learn the principles of VOI or undertake VOI analyses in their projects. The overall goal is to improve the understanding of these methods and make them easier to use.

Perspectives on Big Data Analysis
  • Language: en
  • Pages: 208

Perspectives on Big Data Analysis

This volume contains the proceedings of the International Workshop on Perspectives on High-dimensional Data Analysis II, held May 30-June 1, 2012, at the Centre de Recherches Mathématiques, Université de Montréal, Montréal, Quebec, Canada. This book collates applications and methodological developments in high-dimensional statistics dealing with interesting and challenging problems concerning the analysis of complex, high-dimensional data with a focus on model selection and data reduction. The chapters contained in this book deal with submodel selection and parameter estimation for an array of interesting models. The book also presents some surprising results on high-dimensional data ana...

Case Studies in Innovative Clinical Trials
  • Language: en
  • Pages: 303

Case Studies in Innovative Clinical Trials

  • Type: Book
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  • Published: 2023-11-27
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  • Publisher: CRC Press

Drug development is a strictly regulated area. As such, marketing approval of a new drug depends heavily, if not exclusively, on evidence generated from clinical trials. Drug development has seen tremendous innovation in science and technology that has revolutionized the treatment of some diseases. And yet, the statistical design and practical conduct of the clinical trials used to test new therapeutics for safety and efficacy have changed very little over the decades. Our approach to clinical trials is steeped in convention and tradition. The large, fixed, randomized controlled trial methods that have been the gold standard are well understood and expected by many trial stakeholders. Howeve...

Big and Complex Data Analysis
  • Language: en
  • Pages: 390

Big and Complex Data Analysis

  • Type: Book
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  • Published: 2017-03-21
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  • Publisher: Springer

This volume conveys some of the surprises, puzzles and success stories in high-dimensional and complex data analysis and related fields. Its peer-reviewed contributions showcase recent advances in variable selection, estimation and prediction strategies for a host of useful models, as well as essential new developments in the field. The continued and rapid advancement of modern technology now allows scientists to collect data of increasingly unprecedented size and complexity. Examples include epigenomic data, genomic data, proteomic data, high-resolution image data, high-frequency financial data, functional and longitudinal data, and network data. Simultaneous variable selection and estimati...

ROC Analysis for Classification and Prediction in Practice
  • Language: en
  • Pages: 234

ROC Analysis for Classification and Prediction in Practice

  • Type: Book
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  • Published: 2023-05-15
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  • Publisher: CRC Press

This book presents a unified and up-to-date introduction to ROC methodologies, covering both diagnosis (classification) and prediction. The emphasis is on the conceptual underpinning of ROC analysis and the practical implementation in diverse scientific fields. A plethora of examples accompany the methodologic discussion using standard statistical software such as R and STATA. The book arrives after two decades of intensive growth in both the methods and the applications of ROC analysis and presents a new synthesis. The authors provide a contemporary, integrated exposition of ROC methodology for both classification and prediction and include material on multiple-class ROC. This book avoids lengthy technical exposition and provides code and datasets in each chapter. Receiver Operating Characteristic Analysis for Classification and Prediction is intended for researchers and graduate students, but will also be useful for those that use ROC analysis in diverse disciplines such as diagnostic medicine, bioinformatics, medical physics, and perception psychology.

Histone Recognition
  • Language: en
  • Pages: 284

Histone Recognition

  • Type: Book
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  • Published: 2015-05-29
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  • Publisher: Springer

This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.