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Physics of the Large and the Small
This volume presents a set of pedagogical lectures that introduce particle physics beyond the standard model and particle cosmology to advanced graduate students.
Brain Development
This is the first book about both normal development of the nervous system and how early exposure to alcohol and nicotine interferes with this development. The developing nervous system is highly dynamic and vulnerable to genetic and epigenetic factors that can be additive or synergistic. Disruption of normal brain development leads to an array of developmental disorders. One of the most common of these is mental retardation, the prime cause of which is prenatal exposure to alcohol. As chapters in this book show, alcohol has direct effects on the developing neural system and it affects genetic regulation. Another common neurotoxin is nicotine, and it is discussed in this book for three reaso...
Diabetes Mellitus
This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer’s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.
Emerging Drugs and Targets for Alzheimer's Disease
This volume describes the discovery and development history of the most promising drugs now in development for combating Alzheimer's disease.
General Relativity and Gravitation
Explore spectacular advances in contemporary physics with this unique celebration of the centennial of Einstein's discovery of general relativity.
When Cancer Crosses Disciplines
Ever wondered if your patient''s new symptoms are a manifestation of metastatic disease, treatment effects or are altogether unrelated to the cancer diagnosis; whether herbal remedies interact with cancer treatment; when to refer for genetic testing; or how to provide informed advice regarding dietary and lifestyle modifications?. This volume answers these and many other questions, spanning from cancer prevention to palliative care. Each chapter is comprehensively referenced, to allow the reader to explore related fields in more detail. The book is unique in summarizing a large amount of information that is beyond conventional oncology textbooks. While cancer is treated by multidisciplinary ...
Alcohol, Nutrition, and Health Consequences
Chronic alcohol use is associated with heart, liver, brain, and other organ pathology. Alcohol is a drug of abuse and a caloric food and it causes poor intake and absorption of nutrients, thus playing a major role in many aspects of clinical consequences. Alcohol use lowers consumption of fruit and vegetables, lowers tissue nutrients, and, in some cases, requires nutritional therapy by clinicians. Alcohol, Nutrition, and Health Consequences will help the clinician define the causes and types of nutritional changes due to alcohol use and also explain how nutrition can be used to ameliorate its consequences. Chapters present the application of current nutritional knowledge by physicians and di...
Comprehensive Toxicology
An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version
