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The selection of subjects presented in this volume reflects the broad scope of immunologic interest. Most of the progress in the field depends upon elucidation of the genetic basis underlying the immune system's structure and function, and three important genetic areas are represented. They include presentation of a new group of T cell alloantigens with many similarities to the immunoglobulin isotype markers for B cells, discussion of the recently recognized heterogeneity of Class I MHC antigens, and a review of the structure and function of human Ir genes. Additional areas of expanding interest are indicated by three reviews that derive in part from neighboring fields of science but deal wi...
Acute Phase Proteins covers all major aspects of acute phase proteins (APP) starting with molecular mechanisms regulating their synthesis and ending with their functional significance. The book features 36 chapters addressing such topics as acute phase response and the APP; major APP and their structure and functions; regulation of APP synthesis, the cytokines and hormones implicated in these processes, and molecular mechanisms involved; signal transduction of cytokines in hepatocytes and posttranscriptional processes; and quantitative and qualitative evaluation of APP in clinical practice. The book will be an important reference for immunologists, molecular biologists, cellular biologists, biochemists, and clinical chemists.