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This reference examines innovations in separation science for improved sensitivity and cost-efficiency, increased speed, higher sample throughput and lower solvent consumption in the assessment, evaluation, and validation of emerging drug compounds. It investigates breakthroughs in sample pretreatment, HPLC, mass spectrometry, capillary electrophoresis and therapeutic drug monitoring for improved productivity, precision, and safety in clinical chemistry, biomedical analysis, and forensic research. From saliva, hair, and biological samples to illegal drugs and toxins, Separation Techniques in Clinical Chemistry is a thorough single-source guide for analytical, organic, pharmaceutical, medicinal, physical, surface, and colloid chemists and biochemists; and upper-level undergraduate and graduate students in these disciplines.
Traceability describes the ability of stakeholders to understand and follow relationships between artifacts that play some role in software development. It is essential for many development tasks, e.g., quality assurance, requirements management, or software maintenance. Aiming to overcome various deficiencies of existing traceability concepts, this book presents a universal approach describing required features of traceability solutions. This includes a technology-independent, generic template for the definition of semantically rich traceability relationship types and technology-independent patterns for the retrieval of traceability information, reflecting generic problems common to traceability applications. The universal approach is implemented on the basis of two concrete technologies which facilitate comprehensive traceability: the TGraph approach and OWL ontologies. The applicability of the approach is shown by three case studies dealing with the reuse of software artifacts, process model refinement, and requirements management, respectively.
From the Russian civil wars through the Nazi years, the Jews of Eastern Europe were targets of violence during the first half of the twentieth century. During the Holocaust especially, entire communities were wiped out. In response, survivors sometimes compiled memorial books, or Yizker books, in an attempt to preserve historical, biographical, and cultural information about their shtetls. This multipart collection provides a concise history of the memorial books and their cultural contexts; eight analytical essays on or using Yizker books; key reviews, in some cases translated from the Yiddish, from the 1950s and later; and a bibliographic overview of secondary sources and collections.
For a decade and a half, Biopharmaceutics and Clinical Pharmacokinetics has been used in theclassrooms around the world as an introductory textbook on biophannaceutics and phannacokinetics. Now, the new Fourth Edition, Revised and Expanded further enhances the preceding editions'proven features, introducing significant advances in clinical pharmacokinetics, pharmacokineticdesign of drugs and dosage forms, and model-independent analyses. Still usable without prior knowledge of calculus or kinetics, this successfully implemented workbookmaintains a carefully graduated "building block" presentation, incorporating sample problemsand exercises throughout for a thorough understanding of the materi...
This book provides a coherent methodology for Model-Driven Requirements Engineering which stresses the systematic treatment of requirements within the realm of modelling and model transformations. The underlying basic assumption is that detailed requirements models are used as first-class artefacts playing a direct role in constructing software. To this end, the book presents the Requirements Specification Language (RSL) that allows precision and formality, which eventually permits automation of the process of turning requirements into a working system by applying model transformations and code generation to RSL. The book is structured in eight chapters. The first two chapters present the ma...
This book constitutes the refereed proceedings of the 10th International Conference on Model Driven Engineering Languages and Systems (formerly the UML series of conferences), MODELS 2007, held in Nashville, USA, September 30 - October 5, 2007. The 45 revised full papers were carefully reviewed and selected from 158 initial submissions. The papers are organized in topical sections.
Winner of The Polish Institute of Arts and Sciences of America's 2018 Oskar Halecki Award and Winner of the Early Slavic Studies Association 2016 Book Prize The first fully developed history of the University of Cracow in this period in over a century, “A Pearl of Powerful Learning.” The University of Cracow in the Fifteenth Century places the school in the context of late medieval universities, traces the process of its foundation, analyzes its institutional growth, its setting in the Polish royal capital, its role in national life, and provides a social and geographical profile of students and faculty. The book includes extended treatment of the content of intellectual life and accompl...
Extreme Programming has come a long way since its ?rst use in the C3 project almost 10 years ago. Agile methods have found their way into the mainstream, and at the end of last year we saw the second edition of Kent Beck’s book on Extreme Programming, containing a major refactoring of XP. This year, the 6th International Conference on Extreme Programming and Agile Processes in Software Engineering took place June 18–23 in She?eld. As in the yearsbefore, XP 2005provideda unique forum for industry and academic professionals to discuss their needs and ideas on Extreme Programming and - ile methodologies. These proceedings re?ect the activities during the conference which ranged from present...
This book constitutes the refereed proceedings of the 8th International Conference on Model Driven Engineering Languages and Systems (formerly the UML series of conferences), MoDELS 2005, held in Montego Bay, Jamaica, in October 2005. The 52 revised full papers and 2 keynote abstracts presented were carefully reviewed and selected from an initial submission of 215 abstracts and 166 papers. The papers are organized in topical sections on process modelling, product families and reuse, state/behavioral modeling, aspects, design strategies, model transformations, model refactoring, quality control, MDA automation, UML 2.0, industrial experience, crosscutting concerns, modeling strategies, as well as a recapitulatory section on workshops, tutorials and panels.
In the historiography of trade in the Middle Ages, there is a wide current of theoretical consideration referring to the ways contemporaries perceived trade. The present work pays specific attention to how trade functioned within the range of the influence of the Ottonian Empire and Byzantium, from the 10th to 12th centuries. This book attempts to verify these concepts in the extensive available source. The manner of circulation of goods and the phenomenon of accumulating goods is a significant product of the present book, demonstrating how imperial influences that perceived through the prism of generative centres on the peripheries of Europe. This volume is the English translation of Handel interregionalny od X do XII wieku. Europa Środkowa, Środkowo-Wschodnia, Półwysep Skandynawski i Półwysep Bałkański. Studium Porównawcze (Wydawnictwo Naukowe Uniwersytetu Mikołaja Kopernika,Torun 2016).