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Artificial Intelligence in Medical Imaging
This book provides a thorough overview of the ongoing evolution in the application of artificial intelligence (AI) within healthcare and radiology, enabling readers to gain a deeper insight into the technological background of AI and the impacts of new and emerging technologies on medical imaging. After an introduction on game changers in radiology, such as deep learning technology, the technological evolution of AI in computing science and medical image computing is described, with explanation of basic principles and the types and subtypes of AI. Subsequent sections address the use of imaging biomarkers, the development and validation of AI applications, and various aspects and issues relat...
Johann Michael Wansleben's Travels in the Levant, 1671-1674
Johann Michael Wansleben’s Travels in the Levant, 1671–1674 is a hitherto unpublished version of a remarkable description of Egypt and the Levant by the German scholar traveller Wansleben, or Vansleb (as he was known in France). He set out for the East in 1671 to collect manuscripts and antiquities for the French king and also produced the best study of the Copts to have appeared to date. This book recounts his travels in Syria, Turkey and Egypt, his everyday life in Cairo, and his anthropological and archeological discoveries which include the Graeco-Roman Ǧabbārī cemetery in Alexandria, the Roman city of Antinopolis on the Nile, the Coptic monastery of St Anthony on the Red Sea and the Red and White monasteries in Upper Egypt.
Machine Learning for Drug Discovery
Machine Learning for Drug Discovery is designed to suit the needs of graduate students, advanced undergraduates, chemists or biologists otherwise new to this research domain with minimal previous exposure to Machine Learning (ML) methods, or computational scientists with minimal exposure to medicinal chemistry. The e-book covers basic algorithmic theory, data representation methods, and generative modeling at a high level. The authors spotlight antibiotic discovery as a case study in ML for drug development and discuss diverse applications in drug-likeness prediction, antimicrobial resistance, and areas for future inquiry. For a more dynamic learning experience, open-source code demonstrations in Python are included.
Arctic Oceanography
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Wisconsin Lawyer
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Artificial Intelligence in Drug Design
This volume looks at applications of artificial intelligence (AI), machine learning (ML), and deep learning (DL) in drug design. The chapters in this book describe how AI/ML/DL approaches can be applied to accelerate and revolutionize traditional drug design approaches such as: structure- and ligand-based, augmented and multi-objective de novo drug design, SAR and big data analysis, prediction of binding/activity, ADMET, pharmacokinetics and drug-target residence time, precision medicine and selection of favorable chemical synthetic routes. How broadly are these approaches applied and where do they maximally impact productivity today and potentially in the near future. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step, readily reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and unique, Artificial Intelligence in Drug Design is a valuable resource for structural and molecular biologists, computational and medicinal chemists, pharmacologists and drug designers.
Climate Change and Cultural Dynamics
The Middle Holocene epoch (8,000 to 3,000 years ago) was a time of dramatic changes in the physical world and in human cultures. Across this span, climatic conditions changed rapidly, with cooling in the high to mid-latitudes and drying in the tropics. In many parts of the world, human groups became more complex, with early horticultural systems replaced by intensive agriculture and small-scale societies being replaced by larger, more hierarchial organizations. Climate Change and Cultural Dynamics explores the cause and effect relationship between climatic change and cultural transformations across the mid-Holocene (c. 4000 B.C.). Explores the role of climatic change on the development of society around the world Chapters detail diverse geographical regions Co-written by noted archaeologists and paleoclimatologists for non-specialists
