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Placental Toxicology examines placental transfer and toxicology of drugs and environmental agents to placenta, as well as to fetus. For the first time in a single volume, placental and fetal consequences of exposure of pregnant women to drugs, environmental chemicals, and infections, such as HIV, are discussed. Topics include: The art of in
This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.
This unique reference set provides a broad-based, in-depth presentation on angiotensin II receptors, from the genes that encode them to the responses they mediate in humans. The books emphasize known and potential therapeutic applications of the antagonists of angiotensin II receptors and the angiotensin-converting enzyme inhibitors. The molecular biology of angiotensin II receptors is reviewed, as are the biochemical effects mediated by angiotensin II receptors. This is the first publication to analyze in detail the structure-activity relationships for both peptide and nonpeptide angiotensin II receptor agonists and antagonists. It also presents the pharmacological effects mediated by angiotensin II receptors both in the periphery and in the brain.
With this volume, David Nemec completes his remarkable trilogy of 19th-century baseball biographies, covering every major league player, manager, umpire, owner and league official. It provides in-depth information on many figures unknown to most historians. Each detailed entry includes vital statistics, peer-driven analysis of baseball-related skills, and an overview of the individual's role in the game. Also chronicled are players' first and last major league games, most important achievements, movements from team to team, and much more. By bringing attention to these overlooked baseball personalities, this reference work immeasurably enriches our knowledge of 19th century major league baseball.