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Placental Toxicology
Placental Toxicology examines placental transfer and toxicology of drugs and environmental agents to placenta, as well as to fetus. For the first time in a single volume, placental and fetal consequences of exposure of pregnant women to drugs, environmental chemicals, and infections, such as HIV, are discussed. Topics include: The art of in
Drugs of Abuse and Addiction
Drugs of Abuse and Addiction: Neurobehavioral Toxicology examines drugs of abuse and addiction and how they affect behavior. This book considers the entire range of addiction research in humans and animals, using a multidisciplinary approach to discuss all areas of the neuro- and behavioral sciences involved. Emphasis is on acute and chronic effect
Phospholipase A2 in Clinical InflammationMolecular Approaches to Pathophysiology
Phospholipase A2 in Clinical Inflammation presents an up-to-date topical review of the biochemistry, molecular biology, and biology of mammalian phospholipase A2 (PLA2). The emphasis of this monograph is on the current aspects of PLA2 research using molecular approaches to investigate PLA2 structure and function, inhibitor design, and the regulation of sPLA2 and cPLA2 in cellular systems. The second section examines the major disease states where PLA2 has been implicated: rheumatoid diseases; acute pancreatitis; and psoriasis. These chapters, contributed by experts in the field, give the reader an overall sense of the clinical relevance of the molecular approaches to study PLA2 in relation to the disease entities that may be associated with altered PLA2 levels and activity. This comprehensive text not only provides the necessary historical review for beginning researchers but also addresses the more current molecular approaches as well as the major disease states for the seasoned researcher.
Cell Death
Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme with a wide range of functions, including regulation of DNA repair, cell differentiation, and gene expression. More than a decade after the identification of PARP-like enzymatic activities in mammalian cells, a novel role was proposed for this e
Placental And Endometrial Proteins: Basic And Clinical Aspects
In recent years there has been an enormous growth of interest in the proteins produced by the trophoblast and, most recently, the endometrium, since the knowledge of placental and endometrial proteins is essential for the understanding of the physiology of reproduction. This volume contains reports by 25 internationally renowned experts in this field presented at the 6th International Congress of Placental and Endometrial Proteins which was held in Nagoya, Japan, 1--3 December 1987. Additionally, these proceedings give a unique overview of research done in Japan by publishing over 70 papers by Japanese researchers.
Molecular Bases of Anesthesia
Molecular Bases of Anesthesia provides a clear overview of the state of knowledge about anesthetic mechanisms at the molecular level of occurrence and focusing on the latest state-of-the-art techniques that relate to how anesthetic drugs cause unconsciousness. With contributions by leading experts, this timely book includes chapters on how
The Basis of Toxicity Testing
This substantially updated edition presents fundamental principles and concepts behind the various types of toxicological studies, and explains how to design and conduct studies and interpret results. The text explains the increasing need to monitor, assess, and reevaluate the toxicity database of many agents and evaluates the place of individual studies in the overall toxicological assessment of a chemical. Concise descriptions of the formats of in vivo and in vitro studies and methods used in assessing endpoints of toxicity make this an essential introduction and guide for anyone who needs to understand or conduct toxicological studies. Reflecting increasing interest in the "Three Rs" (Reducing, Refining, and Replacement of existing animal tests) in recent years, the Second Edition includes much more information on a variety of new alternative testing protocols. Particular attention is given to the new in vitro alternative testing procedures being incorporated into EEC regulations. The text also covers studies required by regulatory agencies around the world.
Anabolic Treatments for Osteoporosis
Osteoporosis, a growing epidemic among women in North America, Europe, and Japan, is a painful, costly disease that has presented a treatment challenge to healthcare professionals. Until recently, therapies have focused on agents that slow bone resorption, and have had only limited success at increasing bone mass.
Ryanodine Receptors
This is the first single source to present this important topic from the points of view of many international experts. Chapters written by morphologists, biochemists, pharmacologists, and molecular biologists from around the world are brought together to provide an introductory overview to this key component of intracellular signalling. This ideal text/reference will be useful to students of the basic sciences and medicine as well as professional scientists who want to update their knowledge in this field.
