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The first comprehensive treatment of probabilistic Boolean networks, unifying different strands of current research and addressing emerging issues.
This practical, tutorial-style book uses the Kali Linux distribution to teach Linux basics with a focus on how hackers would use them. Topics include Linux command line basics, filesystems, networking, BASH basics, package management, logging, and the Linux kernel and drivers. If you're getting started along the exciting path of hacking, cybersecurity, and pentesting, Linux Basics for Hackers is an excellent first step. Using Kali Linux, an advanced penetration testing distribution of Linux, you'll learn the basics of using the Linux operating system and acquire the tools and techniques you'll need to take control of a Linux environment. First, you'll learn how to install Kali on a virtual m...
This is the first systematic scholarly study of the Ottoman experience of plague during the Black Death pandemic and the centuries that followed. Using a wealth of archival and narrative sources, including medical treatises, hagiographies, and travelers' accounts, as well as recent scientific research, Nükhet Varlik demonstrates how plague interacted with the environmental, social, and political structures of the Ottoman Empire from the late medieval through the early modern era. The book argues that the empire's growth transformed the epidemiological patterns of plague by bringing diverse ecological zones into interaction and by intensifying the mobilities of exchange among both human and non-human agents. Varlik maintains that persistent plagues elicited new forms of cultural imagination and expression, as well as a new body of knowledge about the disease. In turn, this new consciousness sharpened the Ottoman administrative response to the plague, while contributing to the makings of an early modern state.
The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.
“Development of novel vaccines” gives an overview of the tasks in basic research leading to the final product – the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. Distinct from most textbooks in the vaccine arena, the current issue focuses on the translational aspect, namely, how research results can be transformed into life-saving medical interventions. Each chapter of the book deals with one important paradigm for the development of novel vaccines, along the value chain towards the final vaccine, and furthermore, with the inevitable tools required for this process. Contributions are prepared by teams of scientists, all of whom are experts in the field, most of them anchored in biomedical organizations devoted to translational culture, thereby lighting the certain topics from different views. This volume is a must read for researchers engaged in vaccine development and who really want to see their research results to become a product.
This book provides a comprehensive overview of the state of the art in the field of thermal infrared remote sensing. Temperature is one of the most important physical environmental variables monitored by earth observing remote sensing systems. Temperature ranges define the boundaries of habitats on our planet. Thermal hazards endanger our resources and well-being. In this book renowned international experts have contributed chapters on currently available thermal sensors as well as innovative plans for future missions. Further chapters discuss the underlying physics and image processing techniques for analyzing thermal data. Ground-breaking chapters on applications present a wide variety of ...
This book presents state of the art contributes to Simulated Annealing (SA) that is a well-known probabilistic meta-heuristic. It is used to solve discrete and continuous optimization problems. The significant advantage of SA over other solution methods has made it a practical solution method for solving complex optimization problems. Book is consisted of 13 chapters, classified in single and multiple objectives applications and it provides the reader with the knowledge of SA and several applications. We encourage readers to explore SA in their work, mainly because it is simple and can determine extremely very good results.
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