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The Story of the Tour de France
What they are saying about The Story of the Tour de France: After forty years of study on the subject, I can with some confidence say Bill and Carol McGann's The Story of the Tour de France is the finest such work ever produced in the English language, and perhaps in any. Most of my preferred references are in French, one runs to over 800 pages, yet the McGanns' opus revealed information new to me in almost every paragraph. Their research has been not only impeccable, but insightful. -Owen Mulholland, author of Uphill Battle and Cycling's Golden Age The Story of the Tour de France: How a Newspaper Promotion Became the Greatest Sporting Event in the World by Bill and Carol McGann is a must re...
Intellectual Mastery of Nature. Theoretical Physics from Ohm to Einstein, Volume 2
Winner of the 1987 Pfizer Award of the History of Science Society "A majestic study of a most important spoch of intellectual history."—Brian Pippard, Times Literary Supplement "The authors' use of archival sources hitherto almost untouched gives their story a startling vividness. These volumes are among the finest works produced by historians of physics."—Jed Z. Buchwald, Isis "The authors painstakingly reconstruct the minutiae of laboratory budgets, instrument collections, and student numbers; they disentangle the intrigues of faculty appointments and the professional values those appointments reflected; they explore collegial relationships among physicists; and they document the unending campaign of scientists to wring further support for physics from often reluctant ministries."—R. Steven Turner, Science "Superbly written and exhaustively researched."—Peter Harman, Nature
Shut Up, Legs!
Beloved German cyclist Jens Voigt isn't a superstar in the traditional sense of the word. Although he won three stages of the Tour De France--and wore the yellow jersey twice--Voigt never claimed an overall victory. He became a star because he embodies qualities that go beyond winning and losing: sacrifice, selflessness, reliability, and devotion. European and American crowds were drawn to his aggressive riding style, outgoing nature, and refreshing realness. Voigt adopted a tireless work ethic that he carried throughout his career. In Shut Up, Legs! (a legendary Jensism), Voigt reflects upon his childhood in East Germany, juggling life as a professional cyclist and a father of six, and how he remained competitive without doping. Shut Up, Legs! offers a rare glimpse inside his heart and mind.
In Silico Chemistry and Biology
In Silico Chemistry and Biology: Current and Future Prospects provides a compact overview on recent advances in this highly dynamic branch of chemistry. Various methods of protein modelling and computer-assisted drug design are presented, including fragment- and ligand-based approaches. Many successful practical applications of these techniques are demonstrated. The authors also look to the future and describe the main challenges of the field.
Computational Biology and Machine Learning for Metabolic Engineering and Synthetic Biology
This volume provides protocols for computational, statistical, and machine learning methods that are mainly applied to the study of metabolic engineering, synthetic biology, and disease applications. These techniques support the latest progress in cross-disciplinary research that integrates the different scales of biological complexity. The topics covered in this book are geared toward researchers with a background in engineering, computational analytical, and modeling experience and cover a broad range of topics in computational and machine learning approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Computational Biology and Machine Learning for Metabolic Engineering and Synthetic Biology is a valuable resource for any researcher or scientist who wants to learn more about the latest computational methods and how they are applied toward the understanding and prediction of complex biology.
Prokaryotic Gene Regulation
This volume presents a collection of versatile methodologies to investigate prokaryotic gene regulation, with focus on the different levels of information processing and usefulness for various model organisms, whether archaeal, bacterial, or both. The chapters in this book are divided into four sections. Section One covers methods that enable the study of the structure of the bacterial/archaeal chromosome, the main template for all gene regulatory processes, and its epigenetic modification. Section Two looks at a selection of approaches that enable higher levels of understanding of transcription initiation, a key step in information processing. Section Three discusses the investigation of re...
Advances in Synthetic Biology
This book addresses the design of emerging conceptual tools, technologies and systems including novel synthetic parts, devices, circuits, oscillators, biological gates, and small regulatory RNAs (riboregulators and riboswitches), which serve as versatile control elements for regulating gene expression. Synthetic biology, a rapidly growing field that involves the application of engineering principles in biology, is now being used to develop novel systems for a wide range of applications including diagnostics, cell reprogramming, therapeutics, enzymes, vaccines, biomaterials, biofuels, fine chemicals and many more. The book subsequently summarizes recent developments in technologies for assembling synthetic genomes, minimal genomes, synthetic biology toolboxes, CRISPR-Cas systems, cell-free protein synthesis systems and microfluidics. Accordingly, it offers a valuable resource not only for beginners in synthetic biology, but also for researchers, students, scientists, clinicians, stakeholders and policymakers interested in the potential held by synthetic biology.
