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Dynamics of Bone and Cartilage Metabolism
This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. - Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components - Part II covers the organizational structure and cellular metabolism of bone and cartilage - Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease
Cell Cycle Control and Dysregulation Protocols
Cell Cycle Control and Dysregulation Protocols focuses on emerging methodologies for studying the cell cycle, kinases, and kinase inhibitors. It addresses the issue of gene expression in vivo and in vitro, the analysis of cyclin-dependent kinase inhibitors, protein degradation mediated by the proteosome, the analysis of the transformed cell phenotype, and innovative techniques to detect apoptosis. Because there are already many manuals and protocols available, along with commercial kits and reagents, a variety of the more common techniques have not been included in our book. The protocols described, based on rather sophisticated techniques for in vivo and in vitro studies, consist of molecular biology, biochemistry, and various types of immunoassays. Indeed, the authors have successfully accomplished an arduous task by presenting several topics in the simplest possible manner. We are confident that Cell Cycle Control and Dysregulation Protocols will facilitate and optimize the work of practical scientists involved in researching the cell cycle. We greatly acknowledge the extraordinary contribution of the authors in writing this book.
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Principles of Bone Biology
Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The most current and timely source of information about the biology and patholo...
Osteoporosis
Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up...
RUNX Proteins in Development and Cancer
This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy. The pleiotropic effects of RUNX in d...
Clinical Impact of Bone and Connective Tissue Markers
For many years, biochemical tests have been widely used for the diagnosis, classification, and monitoring of bone and connective tissue disease. However, shortcomings in terms of the specificity and sensitivity of such tests have prompted continual questioning about their clinical usefulness.This book, based on a meeting organized jointly by the University of Uppsala and Pharmacia Diagnostics AB, reviews our current understanding of basic bone and connective tissue biochemistry and the clinical role of biochemical markers specific to related diseases, with special reference to rheumatoid arthritis and osteoporosis.
Molecular And Cellular Approaches To The Control Of Proliferation And Differentiation
Molecular and Cellular Approaches to the Control of Proliferation and Differentiation focuses on molecular and cellular approaches used to control cell proliferation and differentiation. This book discusses the basic mechanisms involved in the regulation of cell growth, emphasizing the coupling of proliferation and the progressive expression of several specific cellular phenotypes. This text is organized into three sections encompassing 12 chapters and begins with an introduction to cell proliferation and how it is regulated by growth factors and nuclear protooncogenes in cell proliferation. The book then discusses mitosis and its investigation by means of the cell biological, genetic, bioch...
Vitamins and Hormones
Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. Now, new discoveries have proved that several of the vitamins function as hormones and many of the substances inferred by the title of the Serial function in signal transduction processes. Accordingly, the Editor-in-Chief has expanded the scope of the Serial to reflect this newer understanding of function- structure relationships in cellular communication. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Volume 55 of Vitamins and Hormones covers steroid hormone action, and includes two additional contributions on calcium and on peptide hormones.
Molecular Biology and Biotechnology
This is one volume 'library' of information on molecular biology, molecular medicine, and the theory and techniques for understanding, modifying, manipulating, expressing, and synthesizing biological molecules, conformations, and aggregates. The purpose is to assist the expanding number of scientists entering molecular biology research and biotechnology applications from diverse backgrounds, including biology and medicine, as well as physics, chemistry, mathematics, and engineering.
