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This volume collates world experts’ insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible. The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA...
This volume collates world experts' insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible. The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA m...
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The DNA-stain content of human metaphase chromosomes is measured using quantitative cytochemistry, scanning cytophotometry, and image processing techniques. This approach is applied to chromosomes from a female with chronic myelogenous leukemia (CML). Measurements are normalized for each cell and expressed on a scale where the sum of the measurements for the 44 autosomal chromosomes is 100 units; the normalized measurements are compared with standard values from eight normal persons. Banding analysis of the leukemic cells show a 9q+/22q- translocation. This is confirmed by the DNA measurements; 0.42 units are involved. In addition, measurements of both leukemic and nonleukemic cells reveal a 9+/20- translocation that cannot be detected visually; 0.12 units are involved. Neither translocation shows a net loss of DNA; any loss exceeding 0.05 units (6 x 106 base pairs of DNA) would be significant (P
A compassionate guide to the cancer journey, from screening and prevention to diagnosis and recovery. A cancer diagnosis can change our lives and the lives of our loved ones in an instant. It leaves us seeking answers to myriad questions and searching for hope. In The Cancer Journey, Dr. Chadi Nabhan demystifies this complex disease and offers a compassionate guide to understanding your diagnosis and treatment options. With decades of experience treating oncology patients, Dr. Nabhan answers your essential questions about cancer, including how it develops, how it is diagnosed, how it is treated, and how to prevent it from returning. He provides suggestions for how readers can prepare for the...