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Statins
STATINS: Understanding Clinical Use was written with you-the busy practitioner-in mind. It covers the class of drugs as a whole, discusses the benefits of statin use, and offers future perspectives on ancillary drug actions beyond cholesterol lowering. Leading expert Jawahar Mehta, MD offers you top-notch guidance based on his research and extensive clinical experience-all in one compact source so you don't have to wade through piles of literature to find the information you want. Pharmacologic and clinical profiles that offer you rationales for using statins to treat a full range of problems. Guidance on when to use statins as a treatment in non-cardiologic events, plus discussions of new therapeutic areas. Coverage of some of the hottest topics in the field, including statins in the primary prevention of atherosclerosis related events, the effects of statins on C-reactive protein and statins and bone.
Biochemical Basis and Therapeutic Implications of Angiogenesis
Angiogenesis is a highly complex phenomenon where new blood vessels are formed for the supply of oxygen and nutrients in different organs of the body. It plays a critical role in both physiological processes such as growth and development as well as pathological processes including cancer and different types of tumors. Angiogenesis is also essential for the regeneration and survival of cells in several disease conditions such as ischemic heart disease (myocardial infarction), atherosclerosis, brain injury (stroke) and diabetes. Since the mechanisms of angiogenesis are organ specific and differ among various diseases, it is proposed to devote one section of this book to the development of angiogenesis in some selected diseases such as cancer, ischemic heart disease, atherosclerosis, diabetes and stroke. It is pointed out that extensive research work in this regard has been carried out in the area of cancer and heart disease, whereas relatively less attention has been paid to studying angiogenesis in other disease conditions.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Antioxidants and Cardiovascular Disease
Generation of oxidants or reactive oxygen species is a natural process of human biology. Mitochondrial respiration, phagocytic activity and cyclooxygenase activation are all essential processes of life, which also generate oxidative species. In humans, chronic oxidative stress often coupled with deficiency of antioxidant defenses is associated with the aging process and can lead to the development of disorders such as cancer and arterial disease. Major cardiovascular conditions in which oxidative damage has been strongly implicated include atherosclerosis, myocardial ischemia and reperfusion, coronary restenosis and congestive heart failure. Compelling evidence points to oxidative stress as ...
Genetic Disorders of the Indian Subcontinent
The Indian subcontinent is a vast land mass inhabited by over one billion people. Its rich and varied history is reflected by its numerous racial and ethnic groups and its distinct religious, cultural and social characteristics. Like many developing countries in Asia, it is passing through both demographic and epidemiological transitions whereby, at least in some parts, the diseases of severe poverty are being replaced by those of Westemisation; obesity, diabetes, and heart disease, for example. Indeed, as we move into the new millennium India has become a land of opposites; on the one hand there is still extensive poverty yet, on the other hand, some of the most remarkable developments in c...
Atherosclerosis, Hypertension and Diabetes
This volume is devoted to atherosclerosis, hypertension, anddiabetes, three of the most important disease conditions in the worldtoday. Nutritional intervention, cholesterol lowering agents, lipidsthemselves, particularly oxidized LDL, protein modification byADP-ribose, bone marrow study, endothelial cell dysfunction, angiotensin, and the role of infection and inflammation are alldiscussed in the context of atherosclerotic cardiovascular disease.The hypertension section focuses on factors that may be responsiblefor high blood pressure, such as genetic predisposition, vascularhyperplasia and remodeling, insulin resistance, neurological aspectssuch as hypothalamic peptides. Also discussed are ...
Biochemical Basis and Therapeutic Implications of Angiogenesis
This book covers the latest developments in the therapeutic implications of angiogenesis, ranging from angiogenesis in the brain, angiogenesis in cancer, angiogenesis’ role in atherosclerosis and heart disease as well as metabolic disorders and peripheral vascular disease. The book is comprehensive in its coverage of angiogenesis in a diverse set of diseases and examines the role of cellular and subcellular structures during the development of angiogenesis. Well-organized and thorough, this is an ideal book for researchers and biomedical engineers working in the field of therapeutic implications of angiogenesis. This book also: Covers the basics of the physiology of angiogenesis, including VEGF pathways in angiogenesis, integr ins in angiogenesis, angiogenesis and exercise physiology, and more Details the role of angiogenesis in atherosclerosis and heart disease, including vascular endothelial growth factor and atherosclerotic plaque progression as well as angiogenesis and heart failure Illustrates in detail brain angiogenesis after stroke and the relationship between angiogenesis and Alzheimer's disease
Oxidative Stress in Heart Diseases
This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.
