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Dynamics and the Problem of Recognition in Biological Macromolecules
From within complex structures of organisms and cells down to the molecular level, biological processes all involve movement. Muscular fibers slide on each other to activate the muscle, as polymerases do along nucleic acids for replicating and transcribing the genetic material. Cells move and organize themselves into organs by recognizing each other through macromolecular surface-specific interactions. These recognition processes involve the mu tual adaptation of structures that rely on their flexibility. All sorts of conformational changes occur in proteins involved in through-membrane signal transmission, showing another aspect of the flexibility of these macromolecules. The movement and f...
Protein Dynamics, Function, and Design
This volume is a collection of articles from the proceedings of the International School of Structural Biology and Magnetic Resonance 3rd Course: Protein Dynamics, Function, and Design. This NATO Advance Study Institute was held in Erice at the Ettore Majorana Centre for Scientific Culture on April 16-28, 1997. The aim of the Institute was to bring together experts applyipg different physical methods to problems of macro molecular dynamics-notably x-ray diffraction, NMR and other forms of spectroscopy, and molecular dynamics simulations. Emphasis was placed on those systems and types of problems-such as mechanisms of allosteric control, signal transmission, induced fit to different ligands w...
Neptune's Militia
Under the leadership of Commodore Alexander Gillon, a prominent Charleston merchant, the South Carolina navy secured the services of the largest warship under any American's command during the American Revolution, the frigate South Carolina. This study examines its design and achievements.
Private Ambition and Political Alliances
Sara Chapman focuses on the Phélypeaux de Pontchartrain family to provide a broad study of institutions & political authority in the early modern French state from 1670 to 1715.
Scotland and France in the Enlightenment
The Scottish and French Enlightenments are arguably the two intellectual movements of the eighteenth century that were most influential in shaping the modern age. The essays in Scotland and France in the Enlightenment explore a wide range of topics of historical relevance to eighteenth-century scholars, while engaging students with broad interdisciplinary interests in the humanities and social sciences. The ways in which Scottish philosophy influenced French painting, how the Encyclopaedia Britannica presented the French Revolution, the impact of Macpherson's Ossian on the development of French Romanticism, the moral education of children, the relation between reflection and perception in the arts and in moral life, humankind's relationship to other animals, and the links between violence and imagination, fear and sanity, are only some of the topics covered. This challenging selection of essays comparing Scottish and French enlightenment views of natural history, jurisprudence, moral philosophy, history, and art history complicates and enriches the notion of Enlightenment, and will inaugurate a new field of Franco-Scottish studies.
Voltaire
We think of Voltaire as the epitome of the Enlightenment; in his own time he was also the most famous and controversial figure in Europe. Davidson tells the whole, rich story of his life (1694-1778) - his early imprisonment in the Bastille; exile in England and his mastery of English; an obsession with money, of which he made a huge amount; a scandalous love life; his infatuation with Frederick the Great; a long exile on the borders of Switzerland; his passion for watch-making; his human rights campaigns and his triumphant return to Paris to die there as celebrity extraordinaire. Throughout all of this Voltaire's life was always informed by two things: a belief in the essential value of toleration in the face of fanaticism; and in the right of every man to think and say what he liked. It is rare to have such a vivid portrait of a great man.
Public Drinking in the Early Modern World Vol 1
This four-volume reset edition presents a wide-ranging collection of primary sources which uncover the language and behaviour of local and state authorities, of peasants and town-dwellers, and of drinking companions and irate wives.
Dynamics, Structure, and Function of Biological Macromolecules
A collection of articles looking at modern structural biology, summarizing the applications of physical methods - such as x-ray diffraction, high resolution nuclear magnetic resonance and molecular dynamics - to the study of protein structure and dynamics. There is a review of contemporary thoughts within the field, looking at the mechanisms of alloateric transitions and allosteric control, the transmission of information within protein structures and the role of dynamics in determining the specificity of protein - ligand interactions. There is also a look at future innovations.
Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes
Proceedings of a NATO ASI held in Antalya, Turkey, August 31 - September 11, 1997
