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Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for indiv...
Over the last ten years or so, it has become commonplace to hear talk of an obscurantist threat linked to a rise in irrationality, manifested mainly by a mistrust of vaccination and conventional medicine. But obscurantism can also be found where we pride ourselves on fighting it. In this case, it is no longer the work of marginal or anti-establishment groups, but of a dominant way of thinking that presents itself as that of science and rationality. The aim of this book is to lift the veil on this obscurantism in power. Through numerous examples, from impeded research into unexplained phenomena such as near-death experiences, to the vast field of medicine where the pharmaceutical industry has cornered the market on proving the usefulness of a treatment, Brice Perrier reveals how reason is transformed into dogmatism and hinders the advancement of knowledge. The aim of the book is not to say what is true or false, nor to settle scientific controversies, but to understand why these debates, which have always been legitimate and even necessary in science, may simply no longer be allowed.
This manual surveys toxins from insects, spiders, mollusks, fish, and snakes which have biotechnological applications. It reviews aspects of toxin origin, their molecular mechanism, and their cellular and pathogenic effects. It also provides methodology for the application of these toxins in the research laboratory. This includes a description of the extraction methods, biochemical characterization, and applications in pharmacological studies.
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This work presents a definitive interpretation of the current status of and future trends in natural products—a dynamic field at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids, and enzymes. With more than 1,800 color figures, Comprehensive Natural Products II features 100% new material and complements rather than replaces the original work (©1999). Reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine Stimulates new ideas am...
Covering the most recent advances in our understanding of toxins from venomous animals and microbes as well as that of their targets, this book expertly addresses the many intriguing and unsolved questions concerning; proteomics studies of the "toxinome", intimate modes of toxin actions, molecular basis of specificity, pleiotropic properties of toxins and structural biology of toxins. Through twenty-seven chapters the authors discuss the role of structural genomics in toxinology, how toxins are subject to accelerated evolution, how toxins can be exploited as models for the design of new drugs, and what the future holds for the treatment of snake bites. In order to address these challenging aspects, the authors have posed crystal-clear questions. Based on the most precise knowledge the attendant reasoning shows how toxinology has become an important area of biochemistry and is directly associated with advances in cellular microbiology, molecular pharmacology, molecular physiology, cell biology, protein engineering and many other disciplines.