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Molecular Biology of Long Non-coding RNAs
Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.
Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis
This special issue of The Enzymes is targeted towards researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This volume discusses Eukaryotic RNases and their partners in RNA degradation and biogenesis. - Contributions from leading authorities - Informs and updates on all the latest developments in the field
Translation Initiation: Extract Systems and Molecular Genetics
For over fifty years the Methods in Enzymology series has been the critically aclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume, the first of three on the topic of Translation Initiation includes articles written by leaders in the field.
Pharmaco-Biotechnology and Nanotechnology
This volume details various interesting aspects of pharmaceutical biotechnology. Some of the contributions here focus on nano-biotechnological aspects of cancer and its detection as nanotechnology is one of the most popular areas of research today. Chapters also discuss biosensors in the area of pharmacology and will serve as a guide for the study of various types of biosensors and their mode of action. The book also considers topics such as pharmacogenetics and nutrigenetics, keeping in mind the recent advancement in biomedical science. Its critical discussion of current research references to molecular pharmacology and molecular biotechnology will allow the reader to decipher the interplay between diet, drugs, and genetic factors for improving human health. The book will be of interest to professional researchers, under-graduate and post-graduate students, and professors, as well as industry practitioners.
Deadenylation
This volume provides new approaches and technologies into roles of poly(A) metabolism in translation, RNA stability, and quality control of gene expression. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Deadenylation: Methods and Protocols aims to pave the way for future investigations of the complex regulatory networks that control mRNA stability and expression.
RNA Turnover in Eukaryotes: Nucleases, Pathways and Analysis of mRNA Decay
Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing identification of the protein factors and cofactors, and mRNA instability elements responsible for mRNA decay allow researchers to build a comprehensive picture of the highly orchestrated processes involved in mRNA decay and its regulation. - Covers the nonsense-mediated mRNA decay (NMD) or mRNA surveillance pathway - Expert researchers introduce the most advanced technologies and techniques to identify mRNA processing, transport, localization and turnover, which are central to the process of gene expression - Offers step-by-step lab instructions, including necessary equipment and reagents
E-Book 151-200
Butler Parker ist ein Detektiv mit Witz, Charme und Stil. Er wird von Verbrechern gerne unterschätzt und das hat meist unangenehme Folgen. Der Regenschirm ist sein Markenzeichen, mit dem auch seine Gegner öfters mal Bekanntschaft machen. Diese Krimis haben eine besondere Art ihre Leser zu unterhalten. Butler Parker ist seinen Gegnern, den übelsten Ganoven, auch geistig meilenweit überlegen. In seiner auffallend unscheinbaren Tarnung löst er jeden Fall. Bravourös, brillant, effektiv – spannendere und zugleich humorvollere Krimis gibt es nicht! E-Book 1: Die Todesarie E-Book 2: Die Kendo-Queen E-Book 3: Parker macht die Sichel schartig E-Book 4: Gangsterschach E-Book 5: Parker zieht de...
Mutation, Randomness, and Evolution
What does it mean to say that mutation is random? How does mutation influence evolution? Are mutations merely the raw material for selection to shape adaptations? The author draws on a detailed knowledge of mutational mechanisms to argue that the randomness doctrine is best understood, not as a fact-based conclusion, but as the premise of a neo-Darwinian research program focused on selection. The successes of this research program created a blind spot - in mathematical models and verbal theories of causation - that has stymied efforts to re-think the role of variation. However, recent theoretical and empirical work shows that mutational biases can and do influence the course of evolution, in...
E-Book 151-160
Butler Parker ist ein Detektiv mit Witz, Charme und Stil. Er wird von Verbrechern gerne unterschätzt und das hat meist unangenehme Folgen. Der Regenschirm ist sein Markenzeichen, mit dem auch seine Gegner öfters mal Bekanntschaft machen. Diese Krimis haben eine besondere Art ihre Leser zu unterhalten. Butler Parker ist seinen Gegnern, den übelsten Ganoven, auch geistig meilenweit überlegen. In seiner auffallend unscheinbaren Tarnung löst er jeden Fall. Bravourös, brillant, effektiv – spannendere und zugleich humorvollere Krimis gibt es nicht! E-Book 1: Die Todesarie E-Book 2: Die Kendo-Queen E-Book 3: Parker macht die Sichel schartig E-Book 4: Gangsterschach E-Book 5: Parker zieht dem "Tiger" Zähne E-Book 6: Parker räumt die "Robis" ab E-Book 7: Parker lässt den "Henker" zittern E-Book 8: Parker ködert Barrakudas E-Book 9: Parker sägt am Nerv des "Paten" E-Book 10: Parker fällt aus alles Wolken
Laboratory Methods in Enzymology: RNA
Methods in Enzymology volumes provide an indispensable tool for the researcher. Each volume is carefully written and edited by experts to contain state-of-the-art reviews and step-by-step protocols. In this volume, we have brought together a number of core protocols concentrating on RNA, complementing the traditional content that is found in past, present and future Methods in Enzymology volumes. - Indispensable tool for the researcher - Carefully written and edited by experts to contain step-by-step protocols - In this volume we have brought together a number of core protocols concentrating on RNA
