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Pemphigus and pemphigoid diseases are a heterogenous group of autoimmune blistering disorders (AIBD) characterized by tissue-bound and circulating autoantibodies against structural proteins of the desmosome and basement membrane zone of the skin and orifice-close mucosal tissues. While strong evidence has been provided that autoantibodies in AIBD are pathogenic, the exact mechanisms of how blister formation is mediated is very different between pemphigus and pemphigoid disorders and yet incompletely understood. Additionally, target antigens for the major AIBDs have already been identified on the molecular level. In contrast, diagnostic assays are not yet available for all autoantibody specif...
The intention of the present volume is to unite the research of a range of scholars who have been working on features of non-standard, vernacular English which show an areal distribution, i.e. which cluster geographically across the world. Features common to an area can be due to (i) shared dialect input, (ii) common but separate innovations after settlement, or (iii) area-internal diffusion from one variety to another and/or others. The relative weighting of these factors is an important topic in the book and is a key focus in the 17 chapters. The book is divided into two large blocks, the first one consisting of case studies (8 chapters) and the second with features complexes (9 chapters). The former look at major anglophone locations from an areal perspective while the latter examine linguistic categories and features with a view to determine whether these could be areally based or not.
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Based on the systematic analysis of large amounts of computer-readable text, this book shows how the English language has been changing in the recent past, and discusses the linguistic and social factors that are contributing to this process.
In this book, 50 experts study the lives of U.S. veterans at work, at home, and in American society as they navigate issues regarding health, gender, public service, substance abuse, and homelessness. The aftermath of modern war includes a population of veterans whose needs last for many decades—far longer than the war itself. This in-depth study looks at life after the military, considering the dual conundrum of a population benefiting from the perks of their duty, yet continuing to deal with trauma resulting from their service, and of former servicemen and servicewomen trying to fit into civilian life—in a system designed to keep them separate. Through two comprehensive volumes, essays...