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Telematics and Computing
This book constitutes the thoroughly refereed proceedings of the 8th International Congress on Telematics and Computing, WITCOM 2019, held in Merida, Mexico, in November 2019. The 31 full papers presented in this volume were carefully reviewed and selected from 78 submissions. The papers are organized in topical sections: GIS & climate change; telematics & electronics; artificial intelligence & machine learning; software engineering & education; internet of things; and informatics security.
Books and Bidders: The Adventures of a Bibliophile
“Genius?” The tall old man with the fan-shaped beard looked eagerly at his companion, then settled back more heavily against the rows and rows of old books lining the walls to the ceiling on all sides of the room. “Of course Edgar was a genius, but in spite of being a gambler and a drunkard—in spite of it, I tell you!” The other, a thin man of lesser years, his long, inquiring face meditative in the twilight, nodded. “You are right,” he agreed. “But what difference did it make? The only question is, would ‘The Raven’ have been any greater without his gambling and drinking? I doubt it.” The argument was on, and my uncle, Moses Polock, would lean forward now and again, wa...
Bioisosteres in Medicinal Chemistry
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
Telomeres and Telomerase in Cancer
Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.
Hormones and Neural Aging: Lessons From Experimental Models
How can we slow the signs of aging? Although aging is a natural process for all living things, doing so without dramatic alterations of health and well-being is an important aim in health care. Understanding this gradual but continuous process is fundamental in order to avoid, or at least improve, aging associated illnesses and conditions. The reviews and studies compiled here address various aspects of the relationship between systemic and central changes during the aging process, with hormonal signals as the important liaison.
Women in Ancient America
This new edition of Women in Ancient America draws on recent advances in the archaeology of gender to reexamine the activities, roles, and relationships of women in the prehistoric Native societies of North, Central, and South America. Women—and women’s work—have been crucial to the survival and success of American peoples since ancient times. And as hunting and foraging societies developed farming techniques and eventually created permanent settlements, women’s roles changed. Karen Olsen Bruhns and Karen E. Stothert consider the various economic adaptations that followed, as well as the ways in which women participated in food production and the specialized industries of their socie...
The Massey-Gilbert Blue Book of Mexico for 1903: A Directory in English of the City of Mexico
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
