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Tuberculosis (TB) remains the prime bacterial infection worldwide with 10.4 million infections and a death toll of 1.7 million people in 2016 according to WHO statistics. Tuberculosis is caused by members of the Mycobacterium tuberculosis complex, facultative intracellular bacteria able to thrive within otherwise potent innate defense cells, the macrophages. In a world of increasing numbers of infections with drug resistant M. tuberculosis strains, the daunting race between developing new therapeutics and emerging resistant strains will hardly produce a winner. This cycle can only be broken by enhancing population wide immune control through a better vaccine as the only one currently in use,...
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and still represents one of the global health threats to mankind. The World Health Organization estimated more than 10 million new cases and reported more than 1.5 million deaths in 2019, thus ranking TB among the main causes of death due to a single pathogen. Standard anti-TB therapy includes four first-line antibiotics that should be administered for at least six months. However, in the case of multi- and extensively drug-resistant TB, second-line medications must be used and these frequently cause severe side effects resulting in poor compliance. Developing new anti-TB drug candidates is therefore of outmost i...
Microbial transmission, the processes by which microbes transit to new environments, is a significant and broad-reaching concept with applications throughout the biological sciences. This collection of reviews, edited by an international team of experts studying and working across a range of disciplines, explores transmission not just as an idea in disease but as a fundamental biological process that acts in all domains of nature and exerts its force on disparate size scales, from the micro to the macro, and across units of time as divergent as a single bacterial replication cycle and the entire course of evolution. In five sections, this overview Defines the concept of transmission and cove...
Tuberculosis: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Tuberculosis: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Tuberculosis: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Advances in Actinobacteria Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Actinomycetales in a concise format. The editors have built Advances in Actinobacteria Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Actinomycetales in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Actinobacteria Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
In The Spiritual Exercises of Saint Ignatius Loyola: Contexts, Sources, Reception, Terence O’Reilly examines the historical, theological and literary contexts in which the Exercises took shape. The collected essays have as their common theme the early history of the Spiritual Exercises, and the interior life of Ignatius Loyola to which they give expression. The traditional interpretation of the Exercises was shaped by writings composed in the late sixteenth century, reflecting the preoccupations of the Counter-Reformation world in which they were composed. The Exercises, however, belong, in their origins, to an earlier period, before the Council of Trent, and the full recognition of this fact, and of its implications, has confronted modern scholars with fresh questions about the sources, evolution, and reception of the work.
This graduate textbook serves as a highly readable guide on vaccines and vaccination in infants, children and adolescents from an European perspective. The first part of the book is dedicated to childhood and adolescent vaccine schedules, maternal and neonatal immunization and safety of vaccines. In a second part we focus on viral and bacterial vaccines. Further chapters discuss pediatric travel vaccines, vaccines in the pipeline and the European registration process. This book is intended to be a reference textbook and will help to standardize the information on vaccines and immunization program in the WHO European Region.
"This set of books represents a detailed compendium of authoritative, research-based entries that define the contemporary state of knowledge on technology"--Provided by publisher.
Gender and Exemplarity in Medieval and Early Modern Spain gathers a series of studies on the interplay between gender, sanctity and exemplarity in regard to literary production in the Iberian peninsula. The first section examines how women were con¬strued as saintly examples through narratives, mostly composed by male writers; the second focuses on the use made of exemplary life-accounts by women writers in order to fashion their own social identity and their role as authors. The volume includes studies on relevant models (Mary Magdalen, Virgin Mary, living saints), means of transmission, sponsorship and agency (reading circles, print, patronage), and female writers (Leonor López de Córdoba, Isabel de Villena, Teresa of Ávila) involved in creating textual exemplars for women. Contributors are: Pablo Acosta-García, Andrew M. Beresford, Jimena Gamba Corradine, Ryan D. Giles, María Morrás, Lesley K. Twomey, Roa Vidal Doval, and Christopher van Ginhoven Rey.
Conventional thermal power generating plants reject a large amount of energy every year. If this rejected heat were to be used through district heating networks, given prior energy valorisation, there would be a noticeable decrease in the amount of fossil fuels imported for heating. As a consequence, benefits would be experienced in the form of an increase in energy efficiency, an improvement in energy security, and a minimisation of emitted greenhouse gases. Given that heat demand is not expected to decrease significantly in the medium term, district heating networks show the greatest potential for the development of cogeneration. Due to their cost competitiveness, flexibility in terms of t...