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Optimization-based Molecular Dynamics Studies of SARS-CoV-2 Molecular Structures
COVID-19 has brought us extensive research databases in the fields of biophysics, biology, and bioinformatics. To extract valuable structural bioinformatic information of SARS-CoV-2 structural and nonstructural proteins, it is necessary to work with large-scale datasets of molecular dynamics (MD) trajectories that need to be optimized. This monograph serves as a comprehensive guide to optimization-based MD studies of the molecular structures of SARS-CoV-2 proteins and RNA. The book begins by performing local optimization, taking into account the three-body movement and optimizing the noncovalent bonds of each molecular structure. The optimized structures reach a transition state that offers ...
Advanced Understanding of Neurodegenerative Diseases
Advanced Understanding of Neurodegenerative Diseases focuses on different types of diseases, including Alzheimer's disease, frontotemporal dementia, different tauopathies, Parkinson's disease, prion disease, motor neuron diseases such as multiple sclerosis and spinal muscular atrophy. This book provides a clear explanation of different neurodegenerative diseases with new concepts of understand the etiology, pathological mechanisms, drug screening methodology and new therapeutic interventions. Other chapters discuss how hormones and health food supplements affect disease progression of neurodegenerative diseases. From a more technical point of view, some chapters deal with the aggregation of prion proteins in prion diseases. An additional chapter to discuss application of stem cells. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases.
Printing and Book Culture in Late Imperial China
"A very useful book on a topic of growing importance and interest. Brokaw's introduction is one of the most valuable and best-written prefaces to an edited volume that I have encountered in some time."—Kent Guy, author of The Emperor's Four Treasures
Opportunity in Crisis
Opportunity in Crisis explores the history of late Qing Cantonese migration along the West River basin during war and reconstruction and the impact of those developments on the relationship between state and local elites on the Guangxi frontier. By situating Cantonese upriver and overseas migration within the same framework, Steven Miles reconceives the late Qing as an age of Cantonese diasporic expansion rather than one of state decline. The book opens with crisis: rising levels of violence targeting Cantonese riverine commerce, much of it fomented by a geographically mobile Cantonese underclass. Miles then narrates the ensuing history of a Cantonese rebel regime established in Guangxi in t...
Chinese Local Elites and Patterns of Dominance
This important volume affords a panoramic view of local elites during the dramatic changes of late imperial and Republic China. Eleven specialists present fresh, detailed studies of subjects ranging from cultivated upper gentry to twentieth-century militarists, from wealthy urban merchants to village leaders. In the introduction and conclusion the editors reassess the pioneering gentry studies of the 1960s, draw comparisons to elites in Europe, and suggest new ways of looking at the top people in Chinese local social systems. Chinese Local Elites and Patterns of Dominance lays the foundation for future discussions of Chinese elites and provides a solid introduction for non-specialists. Essay...
Recent Advances in Crystallography
The advent of X-ray diffraction in the early twentieth century transformed crystallography from an area of scientific inquiry largely limited to physics, mineralogy, and mathematics, to a highly interdisciplinary field which now includes nearly all life and physical sciences as well as materials science and engineering. This book is a collection of works showcasing some of the most recent developments in the field of crystallography.
Sensors: Theory, Algorithms, and Applications
The objective of this book is to advance the current knowledge of sensor research particularly highlighting recent advances, current work, and future needs. The goal is to share current technologies and steer future efforts in directions that will benefit the majority of researchers and practitioners working in this broad field of study.
The Sea of Learning
" In 1817 a Cantonese scholar was mocked in Beijing as surprisingly learned for someone from the boondocks; in 1855 another Cantonese scholar boasted of the flourishing of literati culture in his home region. Not without reason, the second man pointed to the Xuehaitang (Sea of Learning Hall) as the main factor in the upsurge of learning in the Guangzhou area. Founded in the 1820s by the eminent scholar-official Ruan Yuan, the Xuehaitang was indeed one of the premier academies of the nineteenth century. The celebratory discourse that portrayed the Xuehaitang as having radically altered literati culture in Guangzhou also legitimated the academy’s place in Guangzhou and Guangzhou’s place as...
Remote Homeland, Recovered Borderland
Remote Homeland, Recovered Borderland addresses a long-ignored issue in the existing studies of community construction: How does the past failure of an ethnic people to maintain sovereignty over their homeland influence their contemporary reconfigurations of ethnic and national identities? To answer this question, Shao Dan focuses on the Manzus, the second largest non-Han group in contemporary China, whose cultural and historical ancestors, the Manchus, ruled China from 1644 to 1912. Based on deep and rigorous empirical research, Shao analyzes the major forces responsible for the transformation of Manchu identity from the ruling group of the Qing empire to the minority of minorities in China...
