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Current Topics
Breast cancer continues to be a major problem. In Volume 1 of this series we dealt exclusively with topics concerned with therapy. In Volume 2 we explored various aspects of experimental biology which are critical to our developing better methods of diagnosis and treatment. In the pres ent volume, we tum to a series of individual topics of considerable interest, including systemic methods for hormonal ablation, screening for early cancer, male breast cancer, and more. The first chapter addresses the question of why some breast tumors metastasize and others do not. Based on elegant animal tumor models, Kim believes that metastasizing tumor cells are the undesirable by product of the host immune surveillance mechanism. Unstable mem brane structures lead to shedding of membrane constituents, abnormal locomotive properties, and evasion of the host defense system. Factors which alter membrane structure will therefore have to be considered in our approach to the management of early breast cancer.
Genomics and Proteomics Engineering in Medicine and Biology
Current applications and recent advances in genomics and proteomics Genomics and Proteomics Engineering in Medicine and Biology presents a well-rounded, interdisciplinary discussion of a topic that is at the cutting edge of both molecular biology and bioengineering. Compiling contributions by established experts, this book highlights up-to-date applications of biomedical informatics, as well as advancements in genomics-proteomics areas. Structures and algorithms are used to analyze genomic data and develop computational solutions for pathological understanding. Topics discussed include: Qualitative knowledge models Interpreting micro-array data Gene regulation bioinformatics Methods to analyze micro-array Cancer behavior and radiation therapy Error-control codes and the genome Complex life science multi-database queries Computational protein analysis Tumor and tumor suppressor proteins interactions
Experimental Biology
Breast cancer continues to be the focus of intense basic and clinical research. In Valurne 1 of this series we dealt exclusively with topics concerned with therapy. In the present Valurne 2, we turn our attention to the experimental biology which is the foundation for our understand ing of problems concerned with breast cancer etiology, mechanisms of hormone action, cell kinetics, experimental chemotherapy, and markers of tumor burden. The contributors to the volume are all noted scholars who are personally investigating these problems. The first chapter addresses the question, do hormones cause breast cancer? Segaloff provides us with a rational up-to-date overview of the existing data. He concludes that hormones by themselves are not tumor initiators but rather alter the hast environment so that other carcinogens are effective. lt is pointed out that the selection of the modeltest system is critical; one can almost assure any desired result by choosing an ap propriately biased test system. The question of the role of viruses in the etiology of human breast cancer remains unanswered despite elegant studies in mause systems.
Serological Cancer Markers
The purpose of this book-the fourth volume of a series on Can cer Markers-is intended to provide an updated "status report" on today's use of cancer markers in the diagnosis and monitoring of can cer, with an emphasis on cancer markers detected in the serum. It has been 7 years since the publication of the last volume in this series. The 1980, 1982, and 1985 volumes covered the development of cancer markers, not only in their roles of unraveling the basic biology of can cer, but also as increasingly important players in the management of patients with cancer. During the last 7 years we have seen the applica tion of a number of markers identified by monoclonal antibodies, as well as the begin...
DHEW Publication
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Frontiers in Cancer Research
Cancer is a group of different diseases (over 100) characterised by uncontrolled growth and spread of abnormal cells. Cancer can arise in many sites and behave differently depending on its organ of origin. If a cancer spreads (metastasises), the new tumour bears the same name as the original (primary) tumour. Significant progress has been made in recent years in the battle against cancer and in understanding its underlying biological mechanisms. This research progress has resulted in many experimental treatments and cures which establish hope for wide-spread cures. This book brings together important research from around the world in this frontal field.
The Guild Handbook of Scientific Illustration
The Guild Handbook of Scientific Illustration, Second Edition Sponsored by the Guild of Natural Science Illustrators and written by top illustrators, scientists, and industry experts, The Guild Handbook of Scientific Illustration, Second Edition is an indispensable reference guide for anyone who produces, assigns, or simply appreciates scientific illustration. Offering broad coverage and more than 620 outstanding illustrations, this new edition offers up-to-date coverage on all aspects of this specialized field, from illustrating molecules and 3D modeling to important material and advice on copyright and contractual concerns, as well as establishing a freelance business. With step-by-step instructions, in-depth coverage of illustrative techniques and related tools, and helpful advice on the day-to-day business of scientific illustrating, it is easy to see why scientific illustrators refer to this book as their "bible."
