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Bioanalytics
Analytical methods are the essential enabling tools of the modern biosciences. This book presents a comprehensive introduction into these analytical methods, including their physical and chemical backgrounds, as well as a discussion of the strengths and weakness of each method. It covers all major techniques for the determination and experimental analysis of biological macromolecules, including proteins, carbohydrates, lipids and nucleic acids. The presentation includes frequent cross-references in order to highlight the many connections between different techniques. The book provides a bird's eye view of the entire subject and enables the reader to select the most appropriate method for any...
Molecular Biology in Medicinal Chemistry
This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods. With its examination of these novel methods and generous practical advice, this is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.
Nucleic Acids in Chemistry and Biology
The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.
Chemical Biology of Nucleic Acids
This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.
MLA International Bibliography of Books and Articles on the Modern Languages and Literatures
Vols. for 1969- include ACTFL annual bibliography of books and articles on pedagogy in foreign languages 1969-
Produktives Altern und informelle Arbeit in modernen Gesellschaften
Ausgangspunkt für das vorliegende Buch bildete ein nur sechs Seiten umfass- der Beitrag zum Thema ‚Volunteer Work’, den die Herausgeber Anfang 2005 für einen Sammelband mit ersten Ergebnissen auf Basis des Survey of Health,- geing and Retirement in Europe (SHARE) verfasst hatten. Die gute Zusamm- arbeit und das nunmehr geweckte Interesse am ‚produktiven Altern’ führten zu dem Entschluss, bei der Fritz Thyssen Stiftung ein zweijähriges Projekt über ‚Informelle Arbeit von Älteren in Deutschland und Europa’ zu beantragen. Das Projekt wurde Ende 2005 bewilligt und damit das (finanzielle) Fundament für die weitere Zusammenarbeit der Herausgeber gelegt. Daher gilt an dieser Stel...
Peptide Nucleic Acids
Peptide Nucleic Acid (PNA) is an analogue of DNA in which the backbone is a pseudopeptide rather than a sugar. PNA mimics the behaviour of DNA and binds complementary nucleic acid strands. The neutral backbone of PNA results in stronger binding and greater specificity than normally achieved. In addition, the unique chemical, physical and biological properties of PNA have been exploited to produce powerful biomolecular tools, antisense and antigene agents, molecues and biosensors. Important new applications have emerged that could not be performed using oligonucleotides. This book contains state-of-the-art protocols and applications on all aspects of Peptide Nucleic Acids. Concepts are explained clearly and in practical terms and each chapter contains concise background information. Written by leading experts in the field, the book is an invaluable and complete reference work on this novel and exciting area. An essential text for all molecular biologists, biochemists, geneticists, biotechnologists and nucleic acid chemists wishing to keep up with the latest developments.
Altern und bürgerschaftliches Engagement
Das Thema "Altern und Bürgerschaftliches Engagement" gewinnt vor dem Hintergrund des demografischen Wandels zunehmend an Gewicht. Mit der Formel des bürgerschaftlichen Engagements erscheint die alte Ehrenamtlichkeit im neuen Gewande. Wenn Freiwilligenarbeit und bürgerschaftliches Engagement derzeit Konjunktur erleben, so stellt sich zugleich auch die Frage, ob sich diese Formen der gesellschaftlichen Partizipation nicht gerade im Angesicht der leeren öffentlichen Kassen besonderer Beliebtheit erfreuen. Die Idee der Bürger-, Zivil- oder Verantwortungsgesellschaft ist jedoch weit mehr als eine politische Verlegenheitsantwort auf die öffentlichen Haushalte. Bürgerschaftliches Engagement ...
