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Annual Reports in Medicinal Chemistry
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. - Covers findings related to cardiovascular, inflammation, and pulmonary diseases - Examines issues in oncology, from mTor inhibitors to drug targets - Incorporates up-to-date information on drug design and discovery, including delivery to market
Analogue-based Drug Discovery II
Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog discovery and development. Spanning a wide range of therapeutic fields and chemical classes, the two volumes together constitute the first systematic approach to drug analog development. Of interest to virtually every researcher working in drug discovery and pharmaceutical chemistry.
The Spark of Fear
The horror genre is continually being reinvented as societal fears evolve. As technology has developed and become ubiquitous in modern life, horror films have effectively played upon our increasing reliance on technology as a source of anxiety. Focusing on advancements from the advent of electricity to the Internet, this book explores how technology--ostensibly humanity's means of conquering fear and the unknown--has become a compelling and abundant source of dread in horror films.
Capitalizing a Cure
"Capitalizing a Cure takes us into the struggle over accessing a medical breakthrough to investigate the power of finance over business, biomedicine, and public health. When sofosbuvir-based medicines launched in 2013, they promised a cure for millions of patients worldwide with hepatitis C. But their sticker shock-the drug was dubbed "the $1,000-a-day pill"-intensified a global debate over the pricing of new medicines. Weaving extensive historical research with insights from political economy and science and technology studies, Victor Roy demystifies an oft-missed dynamic in this debate: the reach of financialized capitalism into how medicines are made, priced, and valued. His account travels between public and private labs, Wall Street and corporate boardrooms, public health meetings and health centers to trace the ways sofosbuvir-based medicines became financial assets dominated by strategies of speculation and extraction at the expense of access and care. Provocative and sobering, this book illuminates the harmful impact of allowing financial markets to supersede democracy and human health and points to the necessary work of building more equitable futures"--
Cinema, Memory, Modernity
Since its inception, cinema has evolved into not merely a ‘reflection’ but an indispensable index of human experience – especially our experience of time’s passage, of the present moment, and, most importantly perhaps, of the past, in both collective and individual terms. In this volume, Kilbourn provides a comparative theorization of the representation of memory in both mainstream Hollywood and international art cinema within an increasingly transnational context of production and reception. Focusing on European, North and South American, and Asian films, Kilbourn reads cinema as providing the viewer with not only the content and form of memory, but also with its own directions for use: the required codes and conventions for understanding and implementing this crucial prosthetic technology — an art of memory for the twentieth-century and beyond.
‘The President Has Been Shot’
This updated paperback edition of the acclaimed analysis of medical and political events surrounding the attempted assassination of Ronald Reagan includes a new Postscript on the election of 1992 and "the public's right to know " which covers the health problems and disclosures of Bush, Tsongas, Buchanan, Perot, and Clinton in light of the issues of privacy and confidentiality.
Mesoscale Chemistry
In the last few decades great strides have been made in chemistry at the nanoscale, where the atomic granularity of matter and the exact positions of individual atoms are key determinants of structure and dynamics. Less attention, however, has been paid to the mesoscale-it is at this scale, in the range extending from large molecules (10 nm) through viruses to eukaryotic cells (10 microns), where interesting ensemble effects and the functionality that is critical to macroscopic phenomenon begins to manifest itself and cannot be described by laws on the scale of atoms and molecules alone. To further explore how knowledge about mesoscale phenomena can impact chemical research and development a...
Eternal Sunshine of the Spotless Mind
Eternal Sunshine of the Spotless Mind is one of the most widely discussed and thought-provoking films of recent years. This is the first book to explore and address the philosophical aspects of Eternal Sunshine of the Spotless Mind. Beginning with a helpful introduction that places each essay in context, specially commissioned chapters examine the following topics: philosophical issues surrounding love, friendship, affirmation and repetition the role of memory (and the emotions) in personal identity and decision-making the morality of imagination and ethical importance of memory philosophical questions about self-knowledge and knowing the minds of others the aesthetics of the film considered in relation to Gondry’s other works and issues in the philosophy of perception Including a foreword by Michel Gondry and a list of further reading, this volume is essential reading for students interested in philosophy and film studies.
