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Accounts in Drug Discovery
Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high-throughput screening "hits" as well as rational, structure-based design. The chapters include "follow-ons" and "next generation" compounds that aim to improve upon first-generation agents. This volume surveys the range of challenges commonly faced by medicinal chemistry researchers, including the optimization of metabolism and pharmacokinetics, toxicology, pharmac...
From Stoke Mandeville to Stratford
Dr. Brittain documents the history of the summer Paralympic Games and presents it in one accessible and easy-to-read volume that focuses on Great Britain's participation in the games.
The Spark of Fear
The horror genre is continually being reinvented as societal fears evolve. As technology has developed and become ubiquitous in modern life, horror films have effectively played upon our increasing reliance on technology as a source of anxiety. Focusing on advancements from the advent of electricity to the Internet, this book explores how technology--ostensibly humanity's means of conquering fear and the unknown--has become a compelling and abundant source of dread in horror films.
Eternal Sunshine of the Spotless Mind
Joel discovers that his girlfriend has had her memories of their tumultuous relationship erased. Not wishing to be left behind he contacts the inventor of the technique to erase his memories too. The resulting confusion is only compounded when he rediscovers his passion for the girl he has forgotten.
