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Modern Therapeutics in Rheumatic Diseases
Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions.
Intra-articular Corticosteroid Therapy for Knee Osteoarthritis
This book is an essential guide for doctors, rheumatologists, orthopedic specialists, and medical researchers. This comprehensive resource demystifies the use of corticosteroid therapy for knee osteoarthritis, providing clear explanations and insights into the latest research. The book explores the effectiveness of corticosteroid treatment, examines the heterogeneity of knee osteoarthritis, and identifies factors that predict treatment response. Utilizing literature reviews, case studies, and statistical analyses, it offers a thorough understanding of this therapeutic approach. Key findings include the mechanisms of corticosteroid action, clinical management strategies, and ethical considerations, supplemented by real-world case studies and patient experiences. This book is a valuable tool for healthcare professionals aiming to improve patient care and advance their understanding of knee osteoarthritis treatment. Enhance your treatment methods and ensure your patients' wellbeing with this indispensable guide.
Osteoarthritis E-Book
This new companion to Hochberg et al.'s Rheumatology masterwork presents current insights into the causes, detection, and therapy of this condition. It provides "one-stop" coverage of scientific and clinical developments, including new concepts in epidemiology and genetics and pathogenic mechanisms · new developments in diagnostic interventions and prevention · and the very latest concepts in treatment. - Features the work of leading experts in osteoarthritis. - Presents current diagnostic criteria and knowledge of pathogenic mechanisms. - Discusses the very latest advances in treatment, including pharmacologic interventions. - Provides new concepts in epidemiology and genetics of osteoarthritis, including modifiable and non-modifiable risk factors.
Osteoarthritis, Inflammation and Degradation
Osteoarthritis is a public health issue due to its impact in term of handicap. Regarded as a multi-factorial disease, mechanistic and inflammatory theories are no more opposed but, on the contrary, are framed within the same continuum: osteoarthritis, inflammation and degeneration. This book helps readers understand the secrets of this disease.
Principles of Molecular Rheumatology
George Tsokos and a panel of authoritative clinicians and researchers synthesize the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established experts describe the biochemical mechanisms by which apoptosis, cell signaling, complement, lipids, and viruses contribute to disease expression, and detail both immune and nonimmune cell function in rheumatic diseases. Their review of the major rheumatic diseases integrates the cellular, biochemical, and molecular biological mechanisms that are important in rheumatic disease pathogenesis. Path-breaking and illuminating, Principles of Molecular Rheumatology expands the envelope of clinical understanding to reveal the biological roots underlying rheumatologic disease, as well as the nature and roles of the powerful new therapeutics now emerging for its optimal treatment.
Interleukin Protocols
Interleukins are a family of proteins that regulate the maturation, diff- entiation, or activation of cells involved in immunity and inflammation, and belong to a broader family termed cytokines. Collectively these proteins are the key orchestrators of host defense and the response to tissue injury. There are currently 23 different interleukins (numbered from IL-1 to IL-23), although the full extent of the interleukin family will only become clear upon analysis of the human genome sequence. Most important, interleukins are central to the pathogenesis of a wide range of diseases that involve an immune com- nent, including such conditions as rheumatoid arthritis, multiple sclerosis, ulcerative...
Computational Physiology
This open access volume compiles student reports from the 2022 Simula Summer School in Computational Physiology. The reports provide an overview of some tools available to model physiology in excitable tissues across scales and scientific questions. In 2022, Simula held the eighth annual Summer School in Computational Physiology in collaboration with the University of Oslo (UiO) and the University of California, San Diego (UCSD). Each year, the course focuses on modeling excitable tissues, with a special interest in cardiac physiology and neuroscience. Group research projects conducted by graduate students from around the world result in reports addressing problems of physiological importance. Reports may not necessarily represent new scientific results; rather, they can reproduce or supplement earlier studies. Reports from seven of the summer projects are included as separate chapters. The topics represented include multiscale mechanics, electrophysiology, pharmacology, and machine learning.
Calcium in Biological Systems
This volume is based in part upon the proceedings of the Calcium Theme held during the 67th Annual Meeting of the Federation of American Societies for Experimental Biology, which took place in Chicago, AprillO-lS, 1983. The American Society for Pharmacology and Experimental Therapeutics had the primary responsibility for organizing the scientific program with the assistance of other member societies, including the American Physiology Society, American Association of Pathologists, and American Institute of Nutrition. The purpose of the Calcium Theme was to review progress in the diverse areas of investigation bearing on the ubiquitous role of calcium in biological systems. In addition to cont...
The Pain Epidemic
Internationally-recognized pain expert Don Goldenberg helps readers better understand the intricacies of chronic pain through the lens of personal stories, including his own. One out of three Americans lives with chronic pain. Pain is the number one reason we seek medical care and accounts for 40% of doctor visits. Chronic pain is the most common cause of work loss world-wide. The yearly cost of chronic pain in the United States is between $560-$630 billion, higher than that of heart disease, diabetes and cancer combined. Despite this, physicians and the public are woefully ill-informed about chronic pain. The litany of self-help books available to the public are largely misleading, quick-fi...
