Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Integrins in Health and Disease
Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of in...
Integrin-ligand Interaction
The fate of cells is largely controlled by the extracellular matrix. Cells recognize matrix constituents via integrins, a large family of receptors. The manifold structural requirements necessary for the specific interaction between distinct integrins and their respective matrix ligands, as well as the subsequent signal transduction pathways and their influence on cell adhesion, migration and morphology, are the main subjects of this book. It emphasizes in particular the importance of the three-dimensional structure and the conformation of the integrin recognition sites within the ligands; this provides new aspects to our understanding of the high specificity of the communication of cells with distinct members of the extracellular matrix.
Toxins in Drug Discovery and Pharmacology
This book is a printed edition of the Special Issue "Toxins in Drug Discovery and Pharmacology" that was published in Toxins
Chemical and Molecular Approach to Tumor Metastases
This book is a printed edition of the Special Issue "Chemical and Molecular Approach to Tumor Metastases" that was published in IJMS
Base Excision Repair of DNA Damage
Reviews the latest research in the field for researchers and clinicians. After a general introduction to DNA base excision repair, chapters cover uracil DNA glycosylases, repair of oxidized purines in DNA, mammalian mismatch-specific DNA glycosylases, repair of apurinic/apyrimidic sites in DNA by AP endonucleases, mutagenesis of abasic sites, a pro
Methods in Cell-Matrix Adhesion
Critically acclaimed for more than 25 years, the Methods in Cell Biology series provides an indispensable tool for the researcher. Each volume is carefully edited by experts to contain state-of-the-art reviews and step-by-step protocols. Techniques are described completely so that methods are made accessible to users. This volume, Methods of Cell-Matrix Adhesion, contains integrated coverage on cell-matrix adhesion methods. It brings the classical methodologies and the latest techniques together in one concise volume. This coverage includes experimental protocols and their conceptual background for all aspects of cell-matrix adhesion research: the extracellular matrix, adhesion receptors, and the growing number of functional applications of matrix-adhesion in molecular cell biology. Also covered is the purification of the extracellular matrix to functional analyses of cellular responses.
Drug Design of Zinc-Enzyme Inhibitors
Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context. With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibi...
