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cGMP: Generators, Effectors and Therapeutic Implications
After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.
Early Lutheran Baptisms and Marriages in Southeastern Pennsylvania
Pastor Stoever served Lutheran congregations in Pennsylvania and elsewhere: Philadelphia area 1733-1735; Lancaster County 1735-1759, 1777-1779; Berks County 1735-1760s, 1774-1779; York County 1735-1743; Adams County 1735-1742; Lebanon County 1740-1779; Dauphin County 1768-1770; Monocacy and Opequon in Frederick County, Virginia, 1735-1742; and Shenandoah in Shenandoah County, Virginia, 1735-1742.
Early Modern Disputations and Dissertations in an Interdisciplinary and European Context
This volume offers a wide-ranging overview of the 16th-18th century disputation culture in various European regions. Its focus is on printed disputations as a polyvalent media form which brings together many of the elements that contributed to the cultural and scientific changes during the early modern period.
