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Homeostasis and Allostasis of Thyroid Function
The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitu...
Sport in the Modern World — Chances and Problems
Should scientific congresses take place in connection with Olympic Games, and should science be represented not only in the form of applied science engaged in the care of athletes, but also as an informing, reflecting and critical authority? The Organizing Committee for the Games of the XXth Olympiad answered this question in the affirmative, and the results have justified this decision. The invitation sent out by the Organizing Committee was accepted by numerous eminent scholars and many participants from all over the world; it was their merit that the general topic of the congress could be discussed in manifold ways under various aspects and without prejudice. For this reason, they deserve...
Urologie Essentials
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Competing-risk Outcomes After Hematopoietic Stem Cell Transplantation from the Perspective of Time-dependent Effects
Abstract: The success of hematopoietic stem cell transplantation is determined by multiple factors. Additional complexity is conferred by covariables showing time-dependent effects. We evaluated the effect of predictors on competing-risk outcomes after hematopoietic stem cell transplantation in a time-dependent manner. We analyzed 14951 outcomes of adult patients with hematologic malignancies who underwent a first allogeneic transplant. We extended the combined endpoints of disease-free and overall survival to competing-risk settings: disease-free survival was split into relapse and non-relapse mortality. Overall survival was divided into transplant-related mortality, death from other causes and death from unknown causes. For time-dependent effects we computed estimators before and after a covariable-specific cut-point. Patients treated with reduced intensity conditioning had a constantly higher risk of relapse compared to patients treated with myeloablative conditioning. For non-relapse mortality, patients treated with reduced intensity conditioning had a reduced mortality risk but this effect was only seen in the first 4 months after transplantation (hazard ratio: 0.76, P
WISDEX
Includes citations for over 90,000 names in over 250 sources in one alphabetical arrangement.
