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The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitu...
Cette biographie retrace la vie et l'oeuvre de Johannes Sinapius, helléniste en Allemagne, devenu médecin en Italie, ami intime d'Erasme, de Melanchton, de Bucer, de Camerarius, de Calvin et de nombreux autres personnages importants. En appendice, on trouve le texte intégral de sa correspondance, ainsi que celui de sa production littéraire.
pt. 1. List of patentees.--pt. 2. Index to subjects of inventions.
This book presents an interdisciplinary study of the nature of the sixteenth-century dedication that will appeal to not only Neo-Latinists and musicologists but also historians of the book and philologists.